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RESEARCH GROUPS
Group U757
Programme: Hereditary Cancer and Related Syndromes
Lead Researcher: Perona, Rosario Group Members
STAFF MEMBERS: Manguán García, Cristina ASSOCIATED MEMBERS: Carrillo García, Jaime | Sánchez Pérez, Isabel | Sastre Garzón, Leandro
Main lines of research
• Application of a rescue therapy in diseases associated with telomerase activity deficiency . Signalling pathways active in dyskeratosis congenita in response to DNA damage . Improve the activity of nano- particles and lentiviral vectors for gene therapy .
• Development of a therapy base in the GSE24 .2 peptide fro the treatment of short telomeres associa- ted diseases, increase oxidative stress and geentic instability .
• Genetic diagnosis of DC y study of telomere lenght in patients of DC and idiophatic pulmonary fibrosis . Study of models of idiopathic pulmonary fibrosis using stem cells and KO mouse models for DUSP1 .
• Investigation about the activity of GSE24 .2 for the treatment of idiophatic pulmonary fibrosis . • Use of GSE24 .2 for the treatment of ataxia telangiectasia .
174 CIBERER » Annual report 2014
