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Most relevant scientific articles
• JorGe oliVer-De la cruz, JoseFa carrión-naVarro, noemí García-romero, antonio Gutiérrez-martín, elisa lá- zaro-ibañez, carmen escobeDo-lucea, rosario perona, FernanDo lópez-ríos, cristobal belDa-iniesta anD ánGel ayuso-saciDo. (2014) SOX2+ cells from the normal human white matter are able to generate mature oligodendrocytes . Plos One 9(6):e99253 . IF 3,73 . IF 3,73
• c manGuan-Garcia, l. pintaDo-bernincHes, J. carrillo, r macHaDo-pinilla, l sastre, carmen pérez-quilis, isabel esmoris, amparo Gimeno, José luis García-Giménez, FeDerico V . Pallardó and R Perona (2014) Expression of the genetic suppressor element 24 .2 (GSE24 .2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells . Plos One 9(7):e101424 . doi: 10 .1371/journal .pone .0101424 . eCollection 2014 . . IF 3,73
• s.p. eGusquiaGuirre, c. manGuán-García, r. perona, r.m. HernánDez, m. iGartua, J.l. Pedraz . Development and validation of a rapid HPLC method for the quantification of GSE4 peptide in biodegradable PEI- PLGA nanoparticles . Journal of Chromatography B 2014 972:95-101 . IF: 2 .862
• eGusquiaGuirre, c. manGuán-García, l. pintaDo-bernincHes, l. iarriccio, D. carbaJo, F. albericio, m. royo, J.l. peDraz, r.m. HernánDez, r. perona*, m. iGartua* .(2014) Development of surface modified biode- gradable polymeric nanoparticles to deliver GSE24 .2 peptide to cells: a promising approach for the treatment of defective telomerase disorders . Submitted to: European Journal of Pharmaceutics and Biopharmaceutics, TP: Feb 7 . pii: S0939-6411(15)00044-2 A . IF: 3 .826 .* corr authors
• c.benitez-buelGa, ms, l.sancHez-barroso, ms, m.GallarDo, pHD, maría apellániz-ruiz, ms , l. inGlaDa- pérez, pHD, K.yanoWsKi, J.carrillo, l.Garcia-esteVez, i.calVo, r.perona, m.urioste, a.osorio, ma.blasco, c.roDríGuez-antona, J.benitez, (2014) . Impact of chemotherapy on telomere-length in sporadic and familial breast cancer patients . Breast Cancer Research and Treatment . 2014 Dec 21 . 149(2):385-94
Highlights
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas Contact: Instituto de Investigaciones Biomédicas Alberto Sols . C/ Arturo Duperier, 4 . 28029 Madrid Phone: (+34) 91 585 44 63 · E .mail:rperona@iib .uam .es
We have identified a short sequence within the GSE24 .2 peptide of 11 AA termed GSE4 that holds an equivalent biological activity than GSE24 .2 . The in vivo assays in a rat model of pulmonary fibrosis and using PLGA-PEI nanoparticles loaded with GSE4 indicate an antifibrotic activity of this peptide . We have performed genetic diagnosis for dysketatosis congenita in colaboration with the U753 group of CIBERER and detected new mutations within the spanish patients . For pulmonary fibrosis we colaborate with Dr . Maria Molina Molina (CIBERES) to make a non invasive methos of telomere lenght measurement . Our preliminary results of the use og GSE24 .2 in ataxia telangiectasia patient cells indicate that expresion of GSE24 .2 is able to rescue some of the alteration of these cells .
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