Page 182 - MEMOCiberer014-ENG

RESEARCH GROUPS
Group U761
Programme: Sensorineural Pathology
Lead Researcher: Varela Nieto, Isabel Group Members
STAFF MEMBERS: Murillo Cuesta, Silvia | Rodríguez de la Rosa, Lourdes
ASSOCIATED MEMBERS: Baeza Ochoa de Ocariz, María Luisa | Cediel Algovia, Rafael | Celaya Puertolas, Adelaida | Contreras Rodríguez, Julio | De Iriarte Rodríguez, Rocío | García Alcántara, Fernando | Magariños Sánchez, Marta | Martínez Vega, Raquel | Pajares Tarancón, María de los Ángeles | Rivera Rodríguez, Teresa | Sanz López, Lorena | Zubeldia Ortuño, José Manuel
Main lines of research
• Characterization of animal and cellular models of sensorineural hearing loss . - Genetics . Physiopathology of IGF-I deficit using animal and cellular models . Neuroinflammatory sig-
nature and redox balance .
- Environment-genome interaction in animal models of hereditary hearing loss subjected to environ- mental stress: ototoxic agents, noise and vitamin deficiency .
- Associated with aging .
• Identification of potential therapeutic targets and hearing loss progression markers . Role of the activity of pro-inflammatory kinase p38 MAPK in auditory damage and of the loss of function of genes from the RAF (RASopathy) family .
• Testing new therapies with small molecules and stem cells in animal models of sensorineural hearing loss .
• Animal models of retinal degeneration associated with IGF-I deficit and intracellular targets .
182 CIBERER » Annual report 2014