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Most relevant scientific articles
• Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxida- tive stress and impairment of homocysteine metabolism . martínez-VeGa r, GarriDo F, partearroyo t, ceDiel r, zeisel sH, martínez-álVarez c, Varela-moreiras G, Varela-nieto i, paJares ma . FASEB J . 2015 Feb;29(2):418-32 . doi: 10 .1096/fj .14-259283 . Epub 2014 Nov 10 . PMID: 25384423
• IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregula- tion of MEF2 transcription factors in the mouse cochlear nuclei . Fuentes-santamaría V, alVaraDo Jc, roDríGuez-De la rosa l, murillo-cuesta s, contreras J, Juiz Jm, Varela-nieto i. Brain Struct Funct . 2014 Nov 7 . PMID: 25378055
• Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r (fl/fl) double transgenic mice . lópez ip, roDríGuez-De la rosa l, pais rs, piñeiro- HermiDa s, torrens r, contreras J, Varela-nieto i, picHel JG . Transgenic Res . 2015 Apr;24(2):279-94 . doi: 10 .1007/s11248-014-9837-5 . Epub 2014 Sep 20 . PMID: 25238791
• Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex . García-Díaz b, riquelme r, Varela-nieto i, Jiménez aJ, De DieGo i, Gómez-conDe al, matas-rico e, aGuirre Ja, cHun J, peDraza c, santín lJ, FernánDez o, roDríGuez De Fonseca F, estiVill- torrús G . Brain Struct Funct . 2014 Sep 17 . PMID: 25226845
• Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice . roDríGuez-De la rosa l, lópez-HerraDón a, portal-núñez s, murillo-cuesta s, lozano D, ceDiel r, Varela-nieto i, esbrit p . PLoS One . 2014 Feb 4;9(2):e87536 . doi: 10 .1371/journal .pone .0087536 . eCollection 2014 .
Highlights
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas Contact: CSIC, Inst . de Investigaciones Biomédicas (CSIC-UAM) · C/ Arturo Duperier, 4 . 28029 Madrid . Tel .: (+34) 91 585 44 22 · E .mail: ivarela@iib .uam .es http://www .ciberer .es/index .php?option=com_wrapper&Itemid=87
This year we have made progress in participation in projects and European networks focused on the study of the genetic basis of auditory aging . The FP7 AFHELO project for the preclinical study of a new family of molecules derived from cholesterol and two networks . The net COST MouseAge focused on the characterization of animal models of human diseases; and the network TARGEAR which we coordinate (www .targear .eu) and that it has a strong translational component with the Hospital de La Paz (Madrid) and transfer with two international biotechnology and electronics companies, we collaborate in the framework of the FP7-PEOPLE program “Industry-Academia Partnerships and Pathways (IAPP) - Marie Curie Action” .
Scientific milestones include the description of the importance of diet in the progression of age-related hearing loss . Thus, we describe for the first time that folic acid and vitamin B derivatives are essential to maintaining a good hearing and cochlear redox state . Finally, they indicate that hyperhomocysteinemia in plasma may be a diagnosis tool for deafness progression . In parallel, we have further understood of the molecular basis of syndromes associated with deficits in the insulin-like growth factor type 1 (IGF-1) using animal models of deficit on the factor and its high affinity receptor . The total deficit is a rare human disease that causes neurosensorial deafness and alterations in bone growth . We have described in these animal models alterations in the central neurotransmission in the auditory pathway, as well as impaired bone growth caused by the loss of activity of cell survival AKT kinase signaling pathways .
The clinical doctors of the group maintained their specialized healthcare activity .
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