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CIBERES » Annual report 2014
• Description of a mutation in the PhoP/R operon of M . tuberculosis involved in the species-specificity of the strains infecting animals and humans (Gonzalo-Asensio et al ., PNAS2014) .
• Development of new antimicrobials based on phage enzymes (Díaz-Martínez et al ., Antimicrob . Agents Chemother 2013) .
• Dissection of the therapeutic interference of the administration of the macrolide azithromycin in respiratory infection due to Haemophilus influenzae, a bacterial pathogen associated with the progression of COPD (Euba et al ., Ant Agents Chemother, 2015) .
• Dissection of the role of structures of bacterial surfaces (lipopolysaccharide and adhesins), and of an array of functions of the respiratory epithelium during infection due to Haemophilus influenzae, a pathogen associated with the progression of COPD (Morey et al ., Microbiology 2011; López- Gómez et al ., Microbiology 2012; Morey et al ., Infect & Immunity 2013; Euba et al ., PLoS One, 2015) .
• First genomic study of the adaptive evolution of the pathogen Haemophilus influenzae in the respiratory system of a COPD patient which has disclosed a repertoire of new antimicrobial targets currently being studied (Garmendia et al ., PLoS One, 2014) .
• First study of the characterisation of the lifecycle of the pathogen Staphylococcus aureus in the alveolar macrophage .
• Demonstration of the antimicrobial effect of seconeolitsine on DNA topoisomerase I of Staphylo- coccus aureus .