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4 . To study whether the implementation of educational programmes and bundles may decrease the incidence of hospital-acquired pneumonia inside and outside the ICU .
5 . To investigate the best way to treat multiresistant microorganisms .
6 . To investigate the epidemiology, virulence, inflammatory response and clinical outcomes of serotypes of S. pneumoniae causing invasive disease before and after the introduction of the new vaccine PVC 13 .
7 . To investigate new mechanisms of virulence, resistance and treatment of S. pneumoniae . 8 . To use our available animal models of severe pneumonia (P. aeruginosa, MR S. aureus and S.
pneumoniae) for translational research . 9 . To develop new clinical guidelines for the management of community-acquired pneumonia,
hospital-acquired pneumonia and ventilator-associated pneumonia .
Main results until the end of 2014
Between 2011 and 2014 papers have been published in high-impact factor journals and in the first decile the results of which will modify clinical practice . A large number of papers in the area of community-acquired pneumonia and Health Care Associated Pneumonia, in the area of VAP and HAP and major microbiological papers and papers on basic research in pneumococcus must be highlighted . In December 2014 a paper was published in the JAMA which is going to be fundamental in clinical practice (JAMA 2015 Feb 17;313(7):677- 86) . Furthermore, a new international clinical guideline (Clin Microbiol Infect . 2015 Jan 14) published by CIBERES members must be highlighted .
OTHER CLINICAL GUIDELINES:
• Guía multidisciplinar para la valoración pronostica, diagnóstico y tratamiento de la neumonía adquirida en la comunidad . Antoni Torres*, José Barberán, Miquel Falguera, Rosario Menéndez, Jesús Molina, Pedro Olaechea Y Alejandro Rodríguez, en nombre del Group de la Guía Multidisciplinar para el Manejo de la Neumonía Adquirida en la Comunidad; 1,2 Med Clin (Barc) . 2013;140(5):223 .e1–223 .e19 .
• A care bundle approach for prevención of ventilator-associated pneumonia . Rello J, Afonso E, Lisboa T et all . Investigadores del proyecto FADO . Clin Microbiol Infect . Abril de 2013; 19(4):363-9 .
PATENTS AND UTILITY MODELS:
• Inventors (by order of signature): Adela González de la Campa, María Teresa García Esteban, María Amparo Blázquez Ferrer . Title: “Uso de Seconeolitsina y N-Metil-Seconeolitsina para la fabricación de medicamentos” (Use of seconeolitsine and n-methyl-seconeolitsine for the manufacture of medicaments) . Application no .: P200931186 . Country of priority: Spain . Priority date: 17/December/2010 . Proprietor: Instituto de Salud Carlos III, Universidad de Valencia and Consejo Superior de Investigaciones Científicas . Countries to which the patent is extended: International application according to the Patent Cooperation Treaty (PCT): PCT/ES2010/070808 . Date: 23/June/2011
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CIBERES » Annual report 2014