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Most relevant scientific articles
• GarMeNdIa J., VIadaS c., caLataYud L., MeLL J.c., MartI-LLIteraS p., euBa B. et al . Characterization of nontypable Haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection . PLoS ONE . 2014;9(5):- .
• LerY L.M.S., FraNGeuL L., toMaS a., paSSet V., aLMeIda a.S., BIaLek-daVeNet S. et al . Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor . BMC Biology . 2014;12:- .
• puIG c., doMeNech a., GarMeNdIa J., LaNGereIS J.d., MaYer p., caLataYud L. et al . Increased biofilm for- mation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections . Applied and Environmental Micro- biology . 2014;80(22):7088-7095 .
• MeLL Jc, SINha S, BaLaShoV S, VIadaS c, GraSSa cJ, ehrLIch Gd et aL. Complete Genome Sequence of Hae- mophilus influenzae Strain 375 from the Middle Ear of a Pediatric Patient with Otitis Media .Genome announcements . 2014;2(6) .
Highlights
Institution: Fundación de Investigacion Sanitaria de las Islas Baleares Ramon Llull (FISIB) Contact: Fundación de Investigación Sanitaria de las Islas Baleares Ramon Llull (FISIB) Ctra . Sóller km . 12 . Recinto Hospital Joan March . 07110 Bunyola (Mallorca) Phone: (+34) 971 011 780 · E .mail: regueiro@caubet-cimera .es · Website: www .caubet-cimera .es
Our group has become a worldwide reference for lipid A analysis since we have been able to analyze, for the first time, the Lipid A structure from a pathogen during infection without isolating or enriching the organism . This achievement opens the door not only to consider new therapeutic targets but also to study how pathogens present them self to the host . For instance, and as a proof of principle, we have developed a bacterial glycome based microchip that enables us to identify different pathogens according to specific membrane structures (Ringer-Rhodes et al ., Advances RSC, 2015,5,7173-7181) .
We currently apply our progresses in lipid A analysis at the Hospital Universitary Son Espases, which is Balearic’s reference hospital, to clarify how distinct respiratory pathogens (i .e . Pseudomonas aeruginosa, and Haemophilus influenzae) modify their membrane structures in order to colonize permanently the lung becoming a chronic pathogen .
Finally, it is worth to point out that all these advances on Lipid A analysis has allowed us to collaborate with several national and international research groups focused on the study of antibiotics resistance mechanisms of multi resistant pathogens (Beceiro et al, Antimicrob Agents Chemother, 2011; . Conde- Alvarez et al, PLoS Pathog, 2012; . Reinés et al, PLoS Pathog . , 2012; De Majumdar et al, PLoS Pathog, 2015), as has done it to participate in various national (SEPAR 068/2011; SEPAR 054/2011; SAF2012- 39841) and international projects (INBIONET FP7-PEOPLE-2012-ITN) .
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