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• Randomized controlled trial WAHA (WAlnuts for Healthy Aging): effects of a diet enriched with wal- nuts (15% of energy) for 2 y in comparison with a control diet on age-related cognitive decline and macular degeneration in 700 older persons . Other outcomes are 2-y changes in: brain structure and function by MRI, carotid atherosclerosis, body composition corporal, bone mineral density, 24-h am- bulatory blood pressure, lipid profile and circulating inflammation markers, leukocyte telomere leng- th, and miRNAs related to lipid metabolism .
• Cognitive function evaluated by neuropsychological tests and functional brain MRI in familial hyper- cholesterolemia compared to moderate hypercholesterolemia and normolipidemia .
• Cholesterol absorption and synthesis as assessed by determination of plasma non-cholesterol sterols by gas chromatography: quantification, genetic determinants, effect on cardiovascular risk, and asso- ciations with lipid responses to plant sterols, statins, and ezetimibe .
• Influence of long-chain polyunsaturated fatty acids (n-3 from plant and marine sources) on carotid atherosclerosis assessed by ultrasound and MRI .
• Associations of fatty acids profiles in total blood, total plasma and phospholipid fractions with cardio- metabolic risk factors and non-alcoholic fatty liver; genetic determinants of the blood omega-3 index; and fatty acid composition of lipid rafts and intracellular signal transduction .
• Investigation of receptors heterodimeric with RXR (PPAR, FXR, LXR, etc .) and other nuclear receptors participating in energy metabolism in liver, adipose, and skeletal muscle tissues and in macrophages .
• Experimental models of metabolic syndrome in fructose-fed rats and rodent models of senescence . Molecular characterization .
Most relevant scientific articles
• salas-salVadó j., Bullo M., estruCh r., ros e., CoVas M.-i., iBarrola-jurado n. et al . Prevention of diabetes with mediterranean diets: A subgroup analysis of a randomized trial . Annals of Internal Medicine . 2014;160(1):1-10 .
• Martínez-González M.a., estruCh r., Corella d., ros e., salas-salVadó j. Prevention of diabetes with Me- diterranean diets: In response . Annals of Internal Medicine . 2014;161(2):157-158 .
• Martínez-González M.a., toledo e., aros F., Fiol M., Corella d., salas-salVadó j. et al . Extravirgin olive oil consumption reduces risk of atrial fibrillation: The PREDIMED (Prevención con Dieta Mediterránea) trial . Circulation . 2014;130(1):18-26 .
• lóPez-ViCario C., González-Periz a., rius B., Moran-salVador e., GarCía-alonso V., lozano j.j. et al . Mo- lecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non- alcoholic steatohepatitis . Gut . 2014;63(2):344-355 .
• doMeneCh M., roMan P., laPetra j., GarCía de la Corte F.j., sala-Vila a., de la torre r. et al . Mediterra- nean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: One-year randomi- zed, clinical trial . Hypertension . 2014;64(1):69-76 .
Institution: Hospital Clínico y Provincial De Barcelona Contact: Hospital Clínico y Provincial de Barcelona · C/ Villarroel, 170 . 08036 Barcelona Teléfono: (+34) 93 227 93 83 · E .mail: eros@clinic .ub .es
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