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RESEARCH GROUPS
Grupo de Nutrición, Lípidos
y Riesgo Cardiovascular
Programme: P1 . Nutrición
Lead Researcher: Ros Rahola, Emilio Group Members
STAFF MEMBERS: Cofan Pujol, Monserrat | Sala Vila, Aleix .
ASSOCIATED MEMBERS: Alegret Jorda, Marta | Laguna Egea, Juan Carlos | Merlos Roca, Manuel | Nuñez Lucas, Isabel | Ortega Martínez de Victoria, Emilio | Pérez Heras, Ana María | Roglans Ribas, Nuria | Sánchez Peñarroya, Rosa María
Main lines of research
• Study of variants in genes of lipid metabolism that might illustrate the etiology of familial and polyge- nic hypercholesterolemia and severe hypertriglyceridemia .
• Carotid and femoral ultrasound examination, in particular . a) examination of the associations between preclinical atherosclerosis and classical and emergent risk factors and dietary biomarkers, such as polyunsaturated fatty acids in plasma lipid fractions and circulating phytosterols; b) preclinical athe- rosclerosis in the pre-diabetic stage compared with a matched control population, and its temporal evolution .
• Functionality of whole foods and dietary patterns: effects on the serum lipoprotein profile, blood pres- sure as assessed by 24-h ambulatory monitoring, insulin resistance, markers of cholesterol absorption and synthesis and vascular risk, and dietary biomarkers (blood polyunsaturated fatty acids, plasma carotenes and vitamin E, and urinary polyphenols) .
• Specific projects within the PREDIMED study, for which the Group directed the nutritional interven- tion . The main projects deal with the effects of PREDIMED diets on: a) age-related cognitive decline alter intervention for 4 y in a subgroup of 450 participants; b) 5-y incidence of dementia in the whole cohort; c) consumption of alpha-linolenic acid and mortality in the whole cohort; d) fructose intake and mortality in the whole cohort; e) changes in carotid plaque by ultrasound and MRI after interven- tion for 2 y in an subgroup of 150 participants .
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CIBEROBN » Annual report 2014