Page 100 - MEMOCiberobn014-ENG

RESEARCH GROUPS
Regulacion del metabolismo en la obesidad
Programme: P6. Physiopathology of Body Weight Homeostasis
Lead Researcher: Remesar Betlloch, Xavier Group Members
STAFF MEMBERS: Calderón Domínguez, María | Romero Romero, María Mar
ASSOCIATED MEMBERS: Alemany Lamana, Mariano | Ariza Piquer, Javier | Calvo Márquez, Merce | Casals Farre, Nuria | Esteve Rafols, Monserrat | Fernández López, José Antonio | García Gómez, Jorge | Grasa Mar- tínez, Mar | Herrero Rodríguez, Laura | Ramírez Flores, Sara | Serra Cucurull, Dolores
Main lines of research
• Determine how the excess fat in the diet influences the catabolism of amino acids and their role in inflammation . Analysis of urea cycle function in different tissues . Effects of high-energy diets .
• Role of protein binding corticosterone (CBG) in the first stage of inflammation to evaluate the mecha- nism by which hormone fit into the tissue and how can modulate the inflammatory response .
• Role of CPT1 in the development of obesity-induced insulin resistance and type 2 diabetes . In vitro and in vivo studies of fatty-acid oxidation and inflammation in liver and adipose tissue .
• Appetite regulation . Role of fatty acids and CPT1A in the control of food intake . Role of CPT1C in the brain .
• Bioinformatic modeling of CPT1 and its relationship with obesity and type 2 diabetes: in silico design of anti-obesity drugs . Study of derivates from the potential anti-obesity drug C75 and their interaction with CPT1 in vitro, and in vivo in the hypothalamus .
100 CIBEROBN » Annual report 2014