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Most relevant scientific articles
• GóMez-zorita s., Fernández-quintela a., lasa a., aGuirre l., riMando a.M., Portillo M.P. Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet . Jour- nal of Agricultural and Food Chemistry . 2014;62(33):8371-8378 .
• GraCia a., elCoroaristizaBal X., Fernández-quintela a., Miranda j., BediaGa n.G., de PanCorBo M.M . et al . Fatty acid synthase methylation levels in adipose tissue: Effects of an obesogenic diet and phenol compounds . Genes and Nutrition . 2014;9(4) .
• arias n., Miranda j., MaCarulla M.t., aGuirre l., Fernandez-quintela a., andres-laCueVa C. et al . The com- bination of resveratrol and conjugated linoleic acid attenuates the individual effects of these molecules on triacylglycerol metabolism in adipose tissue . European Journal of Nutrition . 2014;53(2):575-582 .
• lasa a., Miranda j., Bullo M., Casas r., salas-salVadó j., larretXi i. et al . Comparative effect of two Mediterranean diets versus a low-fat diet on glycaemic control in individuals with type 2 diabetes . European Journal of Clinical Nutrition . 2014;68(7):767-772 .
• jiMénez-aGüero r, eMParanza ji, BeGuiristain a, Bujanda l, alustiza jM, GarCía e et al . Novel equation to de- termine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery . BMC medicine . 2014;12:137 .
Highlights
Institution: Universidad del País Vasco Contact: Facultad de Farmacia de Vitoria · Po Universidad, 7 . 01006 Vitoria-Gasteiz E .mail: leixuri .aguirre@ehu .es · Website: http://www .nutricionyobesidad .com/
The main research line of our group “Nutrition and Obesity” is a preclinical one devoted to study the health benefits of biomolecules present in foodstuffs, which is supported by Plan Nacional grants . In 2014 we have worked in a project aimed to improving resveratrol effectiveness as an anti-obesity molecule, by mean of its combination with quercetin, another polyphenol which reduces resveratrol metabolism, and thus increases its bioavailability . In this research project we have a patent “Composition and uses for thermogenesis activation” in collaboration with Dr . Palou’s group, another CIBERobn group . This patent focuses on the use of resveratrol and quercetin combinations useful for thermogenesis activation, and their application in overweight an obesity treatment or prevention, as well as in their co-morbilities prevention .
Also working in this research line, we have demonstrated for the first time that pterostilbene, a structural analogue of resveratrol which shows higher bioavailability, reduces body fat in animals fed an obesogenic diet . This study has been carried out in collaboration with the USDA in USA .
Our group also performs activities for knowledge transference to society . We have introduced a program to increase fruit and vegetable consumption among child population by collaborating with the City Hall . It has been applied in Vitoria-Gasteiz in the frame of the City Nutritional Observatory . This program has received two awards: National Prize of Quality (Federación Española de Municipios y Provincias; Red Española de Ciudades Saludables) and Estrategia Naos Award .
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