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Most relevant scientific articles
• Cerdá C., sánChez C., CliMent B., Vázquez a., iradi a., el aMrani F. et al . Oxidative stress and DNA damage in obesity-related tumorigenesis . Advances in Experimental Medicine and Biology . 2014;824:5-17 .
• Fito M., estruCh r., salas-salVadó j., Martínez-González M.a., aros F., Vila j. et al . Effect of the Medite- rranean diet on heart failure biomarkers: A randomized sample from the PREDIMED trial . European Journal of Heart Failure . 2014;16(5):543-550 .
• tresserra-riMBau a., riMM e.B., Medina-reMón a., Martínez-González M.a., de la torre r., Corella d. et al . Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study . Nutrition, Metabolism and Cardiovascular Diseases . 2014;24(6):639-647 .
• BaGan j., saez G.t., torMos M.C., GaValda-esteVe C., BaGan l., leoPoldo-rodado M. et al . Oxidative stress in bisphosphonate-related osteonecrosis of the jaws . Journal of Oral Pathology and Medicine . 2014;43(5):371-377 .
• Galan-Chilet i., tellez-Plaza M., Guallar e., de MarCo G., lóPez-izquierdo r., Gónzalez-Manzano i. et al . Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population- based study . Free Radical Biology and Medicine . 2014;74:229-236 .
Highlights
Institution: Universidad de Valencia Contact: Facultad de Medicina de Valencia Avda . Vicente Blasco Ibáñez, 13 . 46010 Valencia · E .mail: guillermo .saez@uv .es
Scientific collaborations with different research groups involved in The PREDIMED study has been established and conducted . Prominent among them are those in which it has been demonstrated the beneficial role of the Mediterranean diet on various clinical and anthropometric aspects in patients at high cardiovascular risk . It is noteworthy observations in the elderly population in which we assess the state of oxidative stress (OS) and its modulation after different dietary interventions . It should be noted the effect of desaturated fatty acid overloading on antioxidant systems in familial hypercholesterolemia and other dyslipidemias that have made a comparative study and correlation between different markers of inflammation . This resulted in a Doctoral Thesis read in 2014 . Another Doctoral Theses this year has been related with the role of polyphenols as cell growth modulators of various tumor cell lines . In 2014 a research project of Carlos III (FIS PI13 / 01848) Institute for the study of genetic and metabolomics factors in the pathophysiology of morbid obesity was initiated . We have collected and processed more than 150 biological samples from these patients . We have studied the degree of OS and DNA damage before and after being subjected to hypocaloric diet, exercise and bariatric surgery . A significant decrease of EO satus and its correlation with clinical and anthropometric parameters has been observed . Studies of gene and protein expression of DNA repair were started together with the identification of microRNAs as potential markers of clinical outcome of morbid obesity and its complications .
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