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Most relevant scientific articles
• orteGa-azorín C., sorli j.V., estruCh r., asensio e.M., Coltell o., González j.i. et al . Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocar- dial infarction incidence depending on level of adherence to the mediterranean diet in the PREDIMED trial . Circulation: Cardiovascular Genetics . 2014; 7(1):49-58 .
• Corella d., ordoVás j.M. How does the Mediterranean diet promote cardiovascular health? Current progress toward molecular mechanisms: Gene-diet interactions at the genomic, transcriptomic, and epigenomic levels provide novel insights into new mechanisms . BioEssays . 2014;36(5):526-537 .
• Corella d., sorli j.V., estruCh r., Coltell o., orteGa-azorín C., Portoles o. et al . MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial . American Journal of Clinical Nutrition . 2014;100(2):719-731 .
• Corella d., sorli j.V., Gonzalez j.i., orteGa C., Fito M., Bullo M. et al . Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial . Cardiovascular Diabe- tology . 2014; 13(1):- .
• sotos-Prieto M., luBen r., khaw k.-t., warehaM n.j., Forouhi n.G. The association between Mediterra- nean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: An analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk study . British Journal of Nutrition . 2014;112(1):122-131 .
Highlights
Institution: Universidad de Valencia Contact: Facultad de Medicina de Valencia · Avda . Vicente Blasco Ibáñez, 15 . 46010 Valencia E .mail: dolores .corella@uv .es
In 2014 our group has carried out very important contributions in the field of cardiovascular nutrigenomics and the Mediterranean diet . Nutrigenomics need results that provide a higher level of scientific evidence through experimental studies, and our group is an international pioneer providing these results . Thus, our results published in Circulation Cardiovascular Genetics demonstrated a gene-diet interaction between the Mediterranean diet and a functional variant (rs3812316, C771G, Gln241His) in MLXIPL gene (X Max- like protein interacting protein-like) . This gene was first described in 2008 in a GWAs in which our group was involved,as a new gene associated with plasma triglycerides . We now show that this association is mediated by adherence to the Mediterranean diet . When the adherence to the Mediterranean diet is high, the allelic variant G protects against hypertriglyceridemia, but not when adherence is low . Similarly, in the intervention group with Mediterranean diet, the G variant protects against myocardial infarction . This protection is lost in the control group . In another important contribution in the Am J Clin Nutr, we presented pioneering results regarding the interaction between genetics and epigenetics . Thus we have shown that the effect of a polymorphism in a binding site of a microRNA (miR-410) in the lipoproteinlipase gene (LPL-rs13702T> C) is also modulated by the unsaturated fatty acids in the diet and the Mediterranean diet pattern . The protection against hipertriglyceridemia and stroke of the variant allele of this polymorphism only took place in the intervention group with Mediterranean diet . Moreover we have contributed in other works of the PREDIMED and we have continued collaborating with other international groups (Dr . Ordovás in Boston, EPIC, etc) and have participated in several national and international projects (ENPADASI) . .
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