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Most relevant scientific articles
• Castro h., PoMar C.a., PiCo C., sánChez j., Palou a. Cafeteria diet overfeeding in young male rats impairs the adaptive response to fed/fasted conditions and increases adiposity independent of body weight . International Journal of Obesity . 2014 .
• MusinoViC h., Bonet M.l., Granados n., aMenGual j., Von lintiG j., riBot j. et al . ß-Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats . Molecular Nutrition and Food Research . 2014;58(11):2157-2165 .
• torrens j.M., konieCzna j., Palou M., sánChez j., PiCo C., Palou a. Early biomarkers identified in a rat model of a healthier phenotype based on early postnatal dietary intervention may predict the response to an obesogenic environment in adulthood . Journal of Nutritional Biochemistry . 2014;25(2):208-218 .
• reynes B., díaz-rua r., CiFre M., oliVer P., Palou a . Peripheral blood mononuclear cells as a potential source of biomarkers to test the efficacy of weight-loss strategies . Obesity . 2014 .
• konieCzna j., sánChez j., Van sChothorst e.M., torrens j.M., BunsChoten a., Palou M. et al . Identification of early transcriptome-based biomarkers related to lipid metabolism in peripheral blood mononuclear cells of rats nutritionally programmed for improved metabolic health . Genes and Nutrition . 2014;9(1) .
Highlights
Institution: Universidad de las Islas Baleares Contact: Facultad de Ciencias de Mallorca Ctra . de Valldemossa, km 7 .5 . 07122 Palma de Mallorca, Islas Baleares E .mail: andreu .palou@uib .es · Website: http://palou .uib .es
During 2014, the group has continued heading the European Project BIOCLAIMS (“BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food”), which involves 11 partners of 7 countries, funded by the European Union, that attempts to identify new biomarkers of the effects of food and food components on health, based on the new biological technologies, in particular, those of Nutrigenomics . The group is also involved in the European project DIABAT (“Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes”) . This project is focused on brown adipose tissue as a target to increase energy waste using different approaches, including diet, to contribute to prevent/treat obesity and its complications .
Among other aspects, the group has gone in depth in the usefulness of a fraction of blood cells (PBMC) for obtaining early biomarkers of obesity and metabolic alterations related to food unbalances . Noteworthy, it has been identified a “nutrigenomic biomarker” which can predict predisposition to develop obesity . This description is protected as a patent that involves CIBER: “Method for the prediction and/or prevention of overweight, obesity and/or its complications through gene expression analysis” (P201430428), and as a publication (Scientific Reports, ranked first decile in its category) . Related to this, the group has described that a higher tendency to develop obesity can be prevented by the intake of adequate amounts of leptin during lactation .
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