Page 43 - CIBEREHD-2015-eng

Research Groups
Most relevant scientific articles
ChiVa T., riPoll C., sarnaGo f., rinCon d., Gómez-Ca- marero J., Galindo e. eT al. Characteristic haemody- namic changes of cirrhosis may influence the diagnosis of portopulmonary hypertension. Liver International. 2015;35(2):353-361.
rodríGuez-feo J.a., PuerTo m., fernández-mena C., VerdeJo C., lara J.m., diaz-sánChez m. eT al. A new role for reticulon-4B/NOGO-B in the intestinal epithelial barrier function and inflammatory bowel disease. American Jour-
olmedilla l., lisBona C.J., Pérez-Pena J.m., lóPez-Baena J.a., GaruTTi i., salCedo m. eT al. Early Measurement of Indocyanine Green Clearance Accurately Predicts Short- Term Outcomes After Liver Transplantation. Transplanta- tion. 2015.
Cerini f., González J.m., Torres f., PuenTe a., Casas m., Vinaixa C. eT al. Impact of anticoagulation on upper-gas- trointestinal bleeding in cirrhosis. A retrospective multi- center study. Hepatology. 2015;62(2):575-583.
nal of Physiology - Gastrointestinal and Liver Physiology. 2015;308(12):981-993.
laTorre r., VaQuero J., rinCon d., PuerTo m., PonCe m.d., sarnaGo f. eT al. Determinants of platelet count are different in patients with compensated and decompensat- ed cirrhosis. Liver International. 2015.
Highlights
The group has continued to consolidate the research structure of its double-edge clinical and experimen- tal lines. In the last year, the group has incorporated two researchers from competitive calls of Instituto de Salud Carlos III (Río Hortega and Juan Rodes), and has obtained funding for research projects in public (FIS PI15 PI: Rafael Bañares, and PI15/01083 PI: Javier Vaquero) and private (Gilead Fellowship PI: Rita García) calls.
The most relevant results from our group proceed from the clinical as well as the experimental re- search lines. Among the first ones, the group has provided insight into the non-hepatic manifestations of cirrhosis finely characterizing the pulmonary cir- culation in patients with cirrhosis with and without portopulmonary hypertension, as well as defining the determinants of platelet count in cirrhosis as a function of the stage of the disease. In the context of a multi-center study, the group has participated in the characterization of the impact of anticoagula- tion on the evolution of gastrointestinal bleeding in patients with cirrhosis.
Another relevant result is provided by an ample study aiming to determine the predictive ability of In- docyanine green clearance evaluated non-invasive- ly in liver trasnplantation recipients. Based on this study, we were able to elaborate a prognostic index highly discriminant for diagnosing primary dysfunc- tion of the graft.
The group has also identified NOGO-B as a new protein with a relevant role on the intestinal barrier permeability in humans as well as in diverse experi- mental animal models. This study clearly shows the link between our group’s research lines: Gastroenter- ology and Hepatology.
Lastly, the group has been able to elaborate, present and defend (in the first weeks of 2016) several doc- toral Thesis (6) derived from some of the previously mentioned projects.
Institution: Servicio Madrileño de Salud · Contact: Hospital Gregorio Marañón. C/ Ibiza 43. 28009 Madrid Tel.: (+34) 609 042 961 · E.mail: [email protected]
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