Page 44 - CIBEREHD-2015-eng

Research Groups
G0065
Programme: Immunology & Liver Transplantation Lead Researcher: Berenguer Haym, Marina
Group members
STAFF MEMBERS: Carvalho Gomes, Ángela Sofía.
ASSOCIATED MEMBERS: Aguilera Tello, Victoria | Benlloch Pérez, Salvador | Pérez Rojas, Judith | Prieto Cas-
tillo, Martín | Rubín Suárez, Ángel.
Main lines of research
Hepatitis B, C, D and E (clinical, virological and immu- nological studies): Focus on assessing the effective- ness and risk-benefit of new direct-acting antivirals for the treatment of HCV (and to a lesser extent HBV/ HDV) both in immunocompetent and liver transplant patients (pre and posttransplant). Studies performed usually within clinical trials sponsored by industry We also collaborate in national and international real life cohorts. These studies/collaborations have resulted in several publications in first decile journals (some in preparation). We are leading a multicenter study ( FIS project ) assessing interactions between HCV and other viruses, such as CMV. Finally, we have obtained private and public funding for epidemiological studies on the prevalence of HCV infection and selection of cost-effec- tive screening strategies.
Post-liver transplantation (LT) long-term complica- tions: research to study several post-TH complications such as sexual and renal function, diabetes, cardiovas- cular disease and de novo tumors. These studies have resulted in publications in first decile journals. Likewise,
we collaborate with other centers to determine prog- nostic factors for cellular rejection and operational mechanisms involved in tolerance.
Hepatocellular carcinoma (HCC) and LT: Collaboration with the National HCC Registry. We are also collaborat- ing with UCSF and the Radiodiagnostic Department to identify LT failure associated factors.
Wilson’s disease: Collaboration with several national centers(IPPC and the “Mixed Rare Diseases Research Unit”)to perform cellular and genetic studies and gener- ate a database to better understand this disease.
Non-cirrhotic portal hypertension: The group belongs to the Spanish multicenter REHEVASC which aims to study this disease by creating a Spanish database and a bank of blood samples for possible future studies.
Cirrhotic portal hypertension: Collaborations with na- tional groups to improve the management of cirrhotic patients with portal hypertension and portal vein throm- bosis.
44 I Annual report 2015 I CIBEREHD