Page 46 - CIBEREHD-2015-eng

Research Groups
G0026
Programme: Portal Hypertension & Mechanisms of Transition to Cirrhosis Lead Researcher: Bosch Genover, Jaume
Group members
STAFF MEMBERS: Gallego Pinos, Javier | García Caldero, Héctor | García Pras, Ester | Guixe Muntet, Sergi | López Sanjurjo, Cristina Isabel | Mejías Hernández, Marc | Orts Salvador, Lara | Sáez Carceller, Rosa María | Vila Bellmunt, Sergi.
ASSOCIATED MEMBERS: Deulofeu Piguet, Ramon | Escorsell Mañosa, Angeles | Fernández Lobato, Mercedes | García Pagán, Juan Carlos | Gracia Sancho, Jordi | Hernández Gea, Virginia.
Main lines of research
• Factors regulating hepatic microcirculation in normal conditions and in cirrhosis: studies in hepatic perfusion and in isolated sinusoidal en- dothelial cells.
• Regulation of the transcription of protective genes of liver sinusoidal endothelium: relevance in the pathophysiology of portal hypertension, prevention of complications of cirrhosis, in ex vivo liver preservation, and liver aging.
• Interaction between different hepatic cell lines. Importance in maintaining the homeostasis of the liver and on the progression / regression of cirrhosis.
• Angiogenesis and portal hypertension: mech- anisms of regulation / alteration in chronic liver disease and relevance in hepatic fibrosis and on- cogenesis.
• New methods for noninvasive assessment in pa- tients with cirrhosis.
• Prevention of decompensation of cirrhosis.
• Randomized clinical trials of new treatments for portal hypertension and bleeding esophageal and gastric varices.
• Hepatic vascular diseases.
46 I Annual report 2015 I CIBEREHD