Page 65 - CIBERER-2015-eng

Most relevant scientific articles
Research Groups
García-Bermúdez J, Sánchez-araGó m, Soldevilla B, del arco a, nuevo-TapioleS c, cuezva Jm. PKA Phospho- rylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase. Cell Rep. 2015 Sep 29;12(12):2143-55.
SanTacaTTerina F, chamorro m, de arenaS cn, navar- ro c, marTín ma, cuezva Jm, Sánchez-araGó m. Quan- titative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases. J Transl Med. 2015 Feb 18;13:65.
caScaJo mv, aBdelmohSen K, noh Jh, Fernández-ayala dJ, WillerS im, Brea G, lópez-lluch G, valenzuela-vil- laToro m, cuezva Jm, GoroSpe m, SiendoneS e, navaS p. RNA-binding proteins regulate cell respiration and co-
Highlights
We have discovered that IF1 regulates the ATP syn- thetic activity of the mitochondrial ATP synthase. The activity of IF1 is regulated by phosphorylation mediated by a mitochondrial cyclic AMP-depend- ent protein kinase A. Phosphorylation of S39 in IF1 hampers its binding to the synthase and prevents the inhibition of the enzyme activity (Cell Rep; CIBERER collaboration). We have demonstrated the clinical utility of the PROTEOmAb platform for the identification of new biomarkers in myopathy af- fected patients (J Transl Med and Patent; CIBERER collaboration). Moreover, we have contributed to the translation of the PROTEOmAb platform for pheno- typing a murine model of Charcot-Marie-Tooth dis- ease (PLoS Genet; CIBERER collaboration) and as a powerful tool to evidence the therapeutic response to treatment in a murine model of retinitis pigmen- tosa (Sci Rep; CIBERER collaboration). In addition, we have contributed in the characterization of the RNABPs that regulate the biosynthesis of CoQ (RNA Biol; CIBERER collaboration). Dr. Sánchez-Aragó contracted personal of unit 713 of CIBERER up to June 2015, has actively contributed in four of these contributions.
enzyme Q biosynthesis by post-transcriptional regulation of COQ7. RNA Biol. 2015 Dec 21:0. [Epub ahead of print]
marTínez-Fernández de la cámara c, hernández-pinTo am, olivareS-González l, cuevaS-marTín c, Sánchez- araGó m, herváS d, Salom d, cuezva Jm, de la roSa eJ, millán Jm, rodriGo r. Adalimumab Reduces Photore- ceptor Cell Death in A Mouse Model of Retinal Degenera- tion. Sci Rep. 2015 Jul 14;5:11764.
Barneo-muñoz m, Juárez p, civera-TreGón a, yndriaGo l, pla-marTin d, zenKer J, cuevaS-marTín c, eSTela a, Sánchez-araGó m, ForTeza-vila J, cuezva Jm, chraST r, palau F. Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy. PLoS Genet. 2015 Apr 10;11(4):e1005115.
Project: “Función oncogénica de IF1, el inhibidor de la H+ATP sintasa de la mitocondria”. Financed by: Fundación Ramón Areces. Duration from: Juny 2015. To: May 2018. Amount: 125.760 €. PI: José Manuel Cuezva Marcos.
Project: ACCI. CIBERER 2015. Biomarcadores Diag- nóstico de Enfermedades Mitocondriales que afect- an al sistema OXPHOS. Amount: 60.000 €. PIs: E. García Arumi (701), JM Cuezva (713) y MA Martín (723).
Granted Patent Entitled: “Procedimiento y kit de diagnóstico diferencial de una enfermedad que cursa con afectación muscular”. Authors: Fulvio Santacatterina, María Sánchez Aragó y José M. Cuezva. Number: ES2432653 Date of publication: 14/12/2013 Date granted: 10/09/2015. Owners: Universidad Autónoma de Madrid y CIBERER.
Institution: Universidad Autónoma de Madrid
Contact: Centro de Biología Molecular Severo Ochoa · Nicolás Cabrera, 1 · Campus de Cantoblanco UAM. 28049 Madrid · Tels: 91 196 46 18 / 91 196 46 48 · E.mail: [email protected]
Web: http://www.cbm.uam.es/mkfactory.esdomain/webs/cbmso/plt_Lineasinvestigacion.Aspx?Idobjeto=7
CIBERER I Annual report 2015 I 65