Page 99 - CIBERER-2015-eng

Most relevant scientific articles
Research Groups
esPino m, Font-llitJós m, Vilches c, salido e, Prat e, lóPeZ de heredia m, Palacín m, nunes V. Digenic Inher- itance in Cystinuria Mouse Model. PLoS One. 2015 Sep 11;10(9):e0137277. doi: 10.1371/journal.pone.0137277. eCollection 2015.(PMID:26359869)
matsouKas mt, aranguren-iBáñeZ á, loZano t, nunes V, lasarte JJ, Pardo l, PéreZ-riBa m. Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding part-
nagamori s, WiriYasermKul P, esPino-guarch m, oKuY- ama h, naKagomi s, tadagaKi K, nishinaKa Y, BodoY s, taKaFuJi K, oKuda s, KuroKaWa J, ohgaKi r, nunes V, Palacín m, Kanai Y. Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinu- ria-related plasma membrane protein rBAT/SLC3A1. Proc Nat Acad Sciences 2016, www.pnas.org/cgi/doi/10.1073/ pnas. 1519959113 (Trabajo acceptado el 11 de Diciembre de 2015, publicado el 7 de Enero 2016)
ners. Sci Signal. 2015 Jun 23;8(382):ra63. doi: 10.1126/ scisignal.2005918. (PMID:26106221)
Highlights
During 2015, the group has continued working to understand the basis of the amino acids renal re- absorption in kidney by using the mouse knockout models for different heteromeric amino acid trans- porters. Together with Manuel Palacin´s group (U731), we have described: a) cystinuric digenia in mouse (Espino et al., 2015); b) a new cystine renal transporter, AGT1; responsible for the 10-15% cys- tine renal reabsorption (Nagamori yet al., 2016), that could be considered a putative new cystinuria gene; c) the cooperation between LAT2/4Fhc and TAT1 transporters in the neutral amino acids reabsorp- tion, with the participation of Rafa Artuch´s team (U703). We have also studied the possible involve- ment of LAT2 transporter in different diseases as aged-related deafness (in collaboration with Isabel Varela´s group (U761)) and the occurrence of cat- aracts (in collaboration with Prof. Verrey in Zurich)
We have also worked in our FIS project aimed to demonstrate the roll of a compound as a cystine lithiasis modulator and we are analyzing the impli- cation of AGT1 in cystinuria families.
We have been developing our intramural project together with Manuel Palacín (U731) and Antonia Ribes groups (U737); in which we have analyzed organic acids in knockout mice models with ami- noacidurias, showing hiperexcretion of Krebs cycle intermediates in those models for basic amino ac- ids basolateral transporters.
In collaboration with Raul Estevez’s group (U751), we have been searching for other proteins involved in MLC by using transcriptomic analyses of Mlc1-/- mouse model cerebellum samples (project granted by ELA). We are also using this model to test the therapeutical possibilities of a compound for MLC (project partially granted by “La Sonrisa de Hugo” patients’ association).
We have participated in a charity dinner organized by “La Sonrisa de Hugo” with an informative talk about our research on MLC.
Institution: Fundación IDIBELL · Contact: Hospital Duran i Reynals · Gran Vía, s/n, km. 2,7 08907 Hospitalet de Llobregat · Tel.: 93 260 74 06 / 93 260 75 00 Ext: 3327
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