Page 45 - CIBERES-2015-eng

Most relevant scientific articles
Research Groups
FernánDez-BertoLin L., MuLLoL J., Fuentes-PraDo M., roCa-Ferrer J., aLoBiD i., PiCaDo C. et aL. Effect of li- popolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma. PLoS ONE. 2015;10(5).
serra-Pages M., torres r., PLaza J., herrerias a., Costa-Farre C., MarCo a. et aL. Activation of the Pros- taglandin E2 receptor EP2 prevents house dust mite-in- duced airway hyperresponsiveness and inflammation by restraining mast cells’ activity. Clinical and Experimental Allergy. 2015;45(10):1590-1600.
Highlights
MAIN RESEARCH RESULTS: 1. We have demon- strated that bacterial infeccions can reduce the ability of corticosteroids to regulate the expression of antiinflammatory genes (MKP-1, GILTZ). 2. We have demonstrated that agonists of EP2 receptor of prostaglandin E2 exert antiinflammatory effects throught the stabilization of mast cells, preventing their degranulation and the release of proinflamma- tory mast cell products. 3. We have demonstrated that corticosteroids modify the remodelling process present in the airways of inflammatory respiratory diseases by repearing the damaged epithelium and regulating the expression of matrix metalloprotein- ases MMP-1, MMP-2 and MMP-9, as well as the ex- pression of the tissue inhibitor of metalloproteases type I (TIMP-1). 4. Our study have revealed novel lymphnagioleimyomatosis (LAM) markers linked to breast cancer metastasis to the lung, which in turn might guide the assessment of new therapies
De BorJa CaLLeJas F., Martínez-anton a., PiCaDo C., aLo- BiD i., PuJoLs L., vaLero a. et aL. Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps. Laryngoscope. 2015;125(5):E158-E167.
De gariBay g.r., herranz C., LLorente a., Boni J., ser- ra-MusaCh J., Mateo F. et aL. Lymphangioleiomyomato- sis biomarkers linked to lung metastatic potential and cell stemness. PLoS ONE. 2015;10(7).
ainsua-enriCh e., serrano-CanDeLas e., aLvarez-erriCo D., PiCaDo C., sayos J., rivera J. et aL. The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. Journal of Immunology. 2015;194(9):4309- 4318.
for LAM. 5 We have reported that the protein 3BP2 regulates human mast cell survivla by conrolling KIT receptor expression, suggesting its potential as a therapeutic target in mast-cell-mediated inflamma- tory diseases.
CLINICAL GUIDELINES: Members of the research team have participated in the implementation of an International Clinical Guideline: MACVIA-Aria senti- nel Network for allergic rhinitis, MASK-Rhinitis. The new generation guideline implementation. Allergy 2015:70:1372-92).
RESEARCH PROJECTS: 5 active projects financed by official agencies with PIs who are members of the research team. One colaborative project with an- other CIBER, CIBERBBN.
Institution: Hospital Clínic de Barcelona
Contact: Villarroel, 170. 08036 Barcelona · Tel.: 93 451 09 93 · E.mail: [email protected]
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