Page 50 - CIBERSAM-2015-eng

Research Groups
Group 8
Programme: Schizophrenia / Mental Disorders of the Child and Adolescent
Lead Researcher: Fañanas Saura, Lourdes
Group Members
STAFF MEMBERS: Fatjo Vilas Mestre, Mar | Martín García, M. José | Valldeperas Llaberia, Anna.
ASSOCIATED MEMBERS: Arias Sanperiz, Bárbara | Barrantes Vidal, Neus | Córdova Palomera, Aldo | Ibáñez Ribes, Manuel Ignacio | Miret Fallada, Salvador | Mitjans Niubo, Marina | Moya Higueras, Jorge | Ortet Fabregat, Generós | Palma Gudiel, Helena | Papiol Miró, Sergi | Prats Balado, Claudia | Rosa de la Cruz, Araceli.
Main lines of research
Main objectives of research projects leaded by G08 group researchers are:
• The study of genetic and environmental risk factors in mental disease (SCH, BD and MD), and its rela- tionship with clinical-cognitive and brain phenotypes (fMRI, _MRI): case-control designs, family-based studies, and twin-based studies.
• Pharmacogenetics of antidepressants, antipsychot- ics and mood stabilizers.
• The study of early stress (prenatal stress and child- hood and adolescence stress) and its impact on HPA axis dysfunction and the development of externaliz- ing and internalizing psychopathology in early stag- es of life.
• Recognition of epigenetic changes induced by pre- natal psychosocial stressors and childhood abuse, and its association with peripheral biomarkers of im-
mune response and changes in brain neuronal con- nectivity (_connectomics).
• The study of GxE mechanisms present in mental disease and populational intermediate phenotypes, from an etiological continuum hypothesis; with spe- cial relevance for the study of: schizotypy, attenuated psychotic symptoms and depression.
• The development of new psychometric and clinical evaluation instruments, especially in child and ado- lescent population.
Some of these research lines are developed in close col- laboration with other national research groups (CIBER: CIBERSAM and CIBERER) and International research groups, under the coordination of G08 researchers and with some new funded projects:
• Maternal prenatal stress and HPA axis sensiti- zation mediated by 11ß-HSD2 gene epigenetic
50 I Annual report 2015 I CIBERSAM