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signatures and its interplay with childhood psy- chosocial stress in explaining risk for psychopa- thology in adolescence. (PINT1512_IP L. Fañanás (G8)+G1+G4+G5+G22+ Ciberer-U719r+MHI of Manheim.
• Brain development and early stressful conditions in mental Health: the mediating role of epigenètic
mechanisms and neuroimaging correlates (ES-EUEpiBrain)_SAF2015-71526-REDT_MINE- CO Acciones de Dinamización “Redes de Excel- encia”_IP.L.Fañanas (G8)+G4+G24+G25+Ciber- er-U719+MHI of Manheim+ U Paris Descartes+ U Medical Center Utrech+U of Milan.
Most relevant scientific articles
Research Groups
cordoVa-PaloMera a., tornador c., Falcon c., BarGal- lo n., nenadIc I., deco G. et al. Altered amygdalar rest- ing-state connectivity in depression is explained by both genes and environment. Human Brain Mapping. 2015.
FatJo-VIlas M., Prats c., PoMarol-clotet e., lazaro l., Moreno c., González-orteGa I. et al. Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disor- ders and its impact on age at onset and cognitive func- tioning. World Journal of Biological Psychiatry. 2015;1-11.
córdoVa-PaloMera a, FatJó-VIlas M, Gastó c, naVarro V, kreBs Mo, Fañanás l. Genome-wide methylation study on depression: differential methylation and variable meth-
Highlights
The contribution of genetic and environmental factors involved in the resting-state connectivity of the amyg- dala in depression, have hardly been investigated from new mathematical approaches to neuroimaging signal; Aldo Cordova (G8), in collaboration with researchers from Cibersam and CNG FiP University, analyzed the connectivity patterns in a sample of 48 monozygotic twins informative for depressive phenotypes, showing that the risk for depression is mediated by environmen- tal factors that alter the amygdala connectivity (Hum Brain Mapp, 2015); Some of the environmental factors involved in depression are thought to act through epige- netic modifications; Along the same research line, and from a genome-wide methylomic analysis approach, the epigenetic risk profile for depression was inves- tigated from a peripheral lymphocyte model, finding differences in CG sites in relevant genes in glucocor- ticoid signal (Transl Psychiatry, 2015). Mar Fatjo-Vilas (G8), in collaboration with several CIBERSAM groups, revealed the involvement of Neuroregulin gene both in the age of onset and cognitive functioning of patients
ylation in monozygotic twins.Translational psychiatry. 2015;5:e557.
PalMa-GudIel h, córdoVa-PaloMera a, eIxarch e, de- uschle M, Fañanás l. Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis.Epigenetics. 2015;0.
aleMany s, Moya J, IBáñez MI, VIlla h, MezquIta l, or- tet G et al. Research Letter: Childhood trauma and the rs1360780 SNP of FKBP5 gene in psychosis: a replication in two general population samples.Psychological medi- cine. 2015;1-3.
diagnosed with BD, SCH and other spectrum disorders (World J Biol Psychiatry 2015). Other contributions of this group during this period showed that genetic varia- bility in FKBP5 gene explains the differential sensitivity of the subject to stress during the early stages of life, and the subsequent development of PEs symptoms in adulthood, in two separate samples of general popula- tion (Psychological Medicine, 2015).
Other G08 group projects funded in 2015:
• Multicentric study of childhood maltreatment in children and adolescents affected by psychiatric disorders: epigenetic associated signatures and its correlated peripheral inmunological biomarkers _PI15/00097_ PI. L. Fañanás (G8)+ G1+G4+G10.
• Analysis of changes in brain connectivity in schizo- phrenia and its relation to genetic variants involved in the development and function of the excitatory and inhibitory neurons (PI15/01420_IP. Mar Fat- jo-Vilas (G8)+ IP coodinador (G19).
Institution: Universitat de Barcelona · Contact: Facultad de Biologia. Universitat de Barcelona Diagonal, 643. 08028 Barcelona · Tel.: 93 402 14 61 · E.mail: [email protected]
CIBERSAM I Annual report 2015 I 51