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SEFALer
The “Service for Laboratory Animals Phenotyping” came about as a result of cooperation with the Consejo Superior de Investigaciones Científicas (CSIC) and is open to participation by other public-private institutions.
This service has the following objectives: I) Functional and histological phenotyping of animal models of human diseases; II) The archive of genetically modified mice; III) Continued training; IV) Specialised and expert advice in phenotyping; and V) Scientific dissemination and disclosure.
• Auditory, vestibular, respiratory and renal phenotyping, general pathological anatomy, neuro- behavioural (motor, cognitive and emotional), haematological and coagulation system, of demyelising diseases and motor coordination. Over 15 publications have been issued as a result of this work as well as participation in research projects, stressing the COST-BM1402 MouseAGE action. The groups in the SEFAler have also participated in 3 ACCIs during the year.
• Archiving and revitalisation of mutants in the Spanish node of EMMA/Infrafrontier (www.infrafrontier.eu).
• Organising the 7th SEFALer training course “Introduction to research on genetically modified animals” in cooperation with the Colegio de Veterinarios de Madrid and with the participation of CIBERER researchers. This course is accredited by Madrid Community’s Continued Training for Healthcare Professions Commission (3.1 credits). The education resources generated are available online for pupils on the course and teaching staff.
• Sefaler took part in scientific dissemination activities (Researchers’ Night, Science Week, Brain Awareness Week...) and in sessions with patients associations (FIAPAS, ALBA, etc.).
The following achievements of SEFALer units are worthy of mention:
• i) Organising and participating in the 7th Edition of SEFALer Courses, at the Auditory Neuroscience Summer School and at the Symposium Ramón Areces “International Platforms for biomedical research: A focus on rare diseases”; ii) Participation in projects (FP7-AFHELO, FP7-TARGEAR and CDTI) for preclinical assessment of new medications and development of cochlear implants for treatment of hearing loss.
• i) Giving services for pathological anatomy and phenotyping of the renal function. Cooperation with the F1 for histological diagnosis of cochlea samples; ii) Speaker at the 7th Edition of SEFALer Courses.
• i) Development of behavioural phenotyping techniques with predictive value for translational studies and on latest generation videoanalysis techniques; II) Development of a system for analysis and display of Behavioural Big Data). iii) Speaker at the 7th Edition of SEFALer Courses.
• i) Implementation of new protocols for the study of platelet function in flow conditions.
• i) Assessment of the locomotor phenotype and of (immunohistochemical) axonal degeneration in the model of X- linked adrenoleukodystrophy (doble knockout mice Abcd1 and Abcd2 Abcd1-/Abcd2-/-) for Medday company, to test the MD1003 drug, with some very positive results. We go on with functional and molecular analysis of this promising treatment for X-ALD.
• i) Implementation of ultra-superovulation technology (Kumamoto University, Japan), which achieved a fivefold increase in the production of oocytes, reducing the number of animals required for in vitro fertilisation/cryopreservation of embryos; II) Incorporation of Van Gieson and Sirius Red stains for detecting elastin and collagen fibres in histological preparations. iii) Speaker at the 7th Edition of SEFALer Courses.
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