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leaD reSearcHer
Cuezva, José Manuel
Universidad Autónoma de Madrid
Centro de Biología Molecular Severo Ochoa.
Nicolás Cabrera, 1.
Campus de Cantoblanco UAM 28049 Madrid
(+34) 91 196 46 18 (+34) 91 196 46 48
[email protected]
group website
GROUP MEMBERS
Staff members: Núñez de Arenas Flores, Cristina | Santacatterina, Fulvio Associated members: Formentini, Laura | Nuevo Tapioles, Cristina
Main lines of research
• Alterations of biogenesis and/or mitochondrial functions in human pathology due to genetic or epigenetic causes.
• Biosynthesis, assembling and degradation of the mitochondrial oxidative phosphorylation Complex V. Identification and functional characterization of the mRNA binding proteins from the beta-F1-ATPasa subunit.
• Development of cellular and mouse models of disease with alterations in mitochondrial oxidative phosphorylation.
• Development of proteomic platforms for the identification of molecular markers of diagnosis in rare diseases related to energy metabolism.
• Protein expression and development of monoclonal antibodies against mitochondrial proteins and energy metabolism to be used in mitochondrial pathologies diagnostic kits.
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PROGRAMMES
Mitochondrial and Neuromuscular Medicine