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Most relevant scientific articles
• Torres-Vega E., Duran-Moreno M., Sanchez del Pino M., Yanez Y., Canete A., Castel V. et al. Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma. Journal of Neuroimmunology. 2016; 297:98-102.
• Planaguma J., Haselmann H., Mannara F., Petit-Pedrol M., Grunewald B., Aguilar E. et al. Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity. Annals of Neurology. 2016;80(3):388-400.
• Guasp M., Sola-Valls N., Martinez-Hernandez E., Gil M.P., Gonzalez C., Brieva L. et al. Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67). Journal of Neuroimmunology. 2016; 300:15-17.
Hightlights
• Findings for anti-NMDA receptor encephalitis
We used a mouse model of chronic cerebroventricular infusion of patients’ NMDA receptor antibodies to demonstrate the antibody pathogenicity at multiple levels and that all antibody mediated effects can be at least partially prevented by administration of ephrin-B2, suggesting a novel molecular intervention with potential therapeutic implications for how to treat patietns with this disorder.
• Findings related to disordes associated with antibodies to GAD67
Adult onset cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against GAD65. We demonstrated that there are patients with this disorder who are negative for GAD65 antibodies but who have antibodies to GAD67. This work demonstrates that GAD67 antibodies are biomarkers of autoimmune cerebellar ataxia and screening for these antibodies should be considered in adults with subacute onset of cerebellar ataxia when GAD65 antibodies are absent.
• Findings related to neuroblastoma associated opsoclonus-myoclonus.
To date a variety of autoimmune biomarkers have been found in patients with neuroblastoma associated opsoclonus-myoclonus but the predominat marker remain unknown. In this study we identified the Shaw-potassium channel Kv3.3 (KCNC3) as a potential antigenic target. Studies are now on-going to confirm this association and determine the clinical utiltiy of finding these antibodies in children with the disorder.
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