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leaD reSearcHer
Garesse, Rafael
Universidad Autónoma de Madrid
Ctra. Colmenar Viejo,
KM 15,500
28049 Madrid
(+34) 91 497 54 52 [email protected] group website
GROUP MEMBERS
Staff members: Gallardo Pérez, María Esther
Contratados a cargo de proyecto: Moreno Moreno, Beatriz
Associated members: Fernández Moreno, Miguel Ángel | Galera Monge, Teresa | Zurita Díaz, Francisco
Main lines of research
• Identification and characterization of new proteins involved in the regulation of the OXPHOS system.
• Functional analysis by means of transmitochondrial cybrids of mutations identified in the
mitochondrial genome associated with LHON and neurosensorial deafness.
• Molecular characterization of patients with intergenomic communication defects.
• Mitochondrial diseases with predominant phenotypic expression in cardiac muscle: Molecular
characterization and analysis by means of transmitochondrial cybrids of new mutations identified in
the mitochondrial genome.
• Development of animal models of mitochondrial diseases in Drosophila melanogaster.
• Generation of iPS cells harboring mutations in structural and regulator genes of the OXPHOS function.
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PROGRAMMES
Mitochondrial and Neuromuscular Medicine