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leaD reSearcHer
Giraldo Castellano, Pilar
Instituto Aragonés de Ciencias de la Salud
Hospital Miguel Servet
Avda. de Ciba. Campus San Francisco. 50009 Zaragoza
(+34) 670 285 339 /
976 761 283 /976 762 842
group website
GROUP MEMBERS
Staff members: Irún Irún, María Pilar
Contratados a cargo de proyecto: Cebolla Sanz, Jorge Javier
Associated members: Andrade Campos, Marcio | Capablo Liesa, José Luis | Köhler, Ralf | Latre Martínez, Paz | Roca Espiau, Mercedes | Sáenz de Cabezón Álvarez, Alicia
Main lines of research
• Gaucher disease epidemiology, in Spain: National Registry acredited by ISO 9001 (Num EC2751/07).
• Genetic analysis and search of genes related to clinical heterogeneity. Directed mutagenesis. DNA,
serum, plasma and leukocyte patient samples biobank.
• Study of biomarkers and inflammatory cytokines and its relationship with response to treatment.
• Study of bone disease by imaging techniques and its relationship with plasma biomarkers.
• Neurological disease evaluation by clinical, neurophysiological and imaging methods.
• Clinical research of new drugs on clinical trials (OGT-011, TKT034, TKT039, Protalix). Independent
clinical trial.
• Epidemiology of hematological neoplasias. Gene expression marker study and search of
polymorphisms accounting for familial aggregations.
• Approach to study of internalization of nanoparticles containing small drug molecules on monocytes
and macrophages and application to treat deposit diseases.
• Analysis of the effect of pharmacological chaperones on protein mutants in Gaucher Disease.
• Plasma miRNAs profile in Haematological malignancies and predictor use to developed acute
leukaemia.
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PROGRAMMES
Inherited Metabolic Medicine