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González Manchón, Consuelo
Agencia Estatal Consejo Superior de Investigaciones Científicas
Centro de Inv. Biológicas Ramiro de Maeztu, 9
28040 Madrid
(+34) 91 837 31 12 ext 4221 [email protected] group website
GROUP MEMBERS
Staff members: Porras Franco, María de Gracia
Associated members: Martín Requero, Ángeles | Sánchez Ayuso, Matilde Main lines of research
• Development and characterization of conditional knockout mice for Cd40lg with specific gen ablation at different steps of hematopoietic development, animal models of X-linked hyper IgM.
• Production of mice with conditional ablation of podocalyxin (Podxl) in vascular endothelial cells as a model for the study of human vasculitis.
• Molecular basis of hemorrhagic syndromes (Glanzmann thrombasthenia, Bernard-Soulier syndrome, FXIII deficiency, among others).
• Establishment of lymphoblastoid cell lines from patiens with Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (associated with mutations in progranulin), and Alzheimer Disease for systemic study of the mechanisms controlling cell survival/death associated with neurodegeneration.
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PROGRAMMES
Genetic Medicine
