Page 62 - MemoriaCIBER-2018ENG

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Scientific Programmes
Liver injury mechanisms / evolution into advanced cirrhosis and transplantation
researchers through specific strategic actions of the CIBEREHD. To be more explicit, the development of a mouse model with humanised liver is enabling different experimental approaches based on that model; the network established for research into the role of extracellular vesicles has furthermore obtained some relevant scientific results which are
Coordinator:
Rafael Bañares Cañizares
The work done by Programme 1 in 2018 has gone on developing in the strategic approach set by the CIBEREHD. We should highlight the wide range of its research work covering practically all liver diseases, excluding liver cancer and viral hepatites.
As part of the priority strategic lines we should stress the promotion of international relations; as occurred in earlier years, collaboration schemes with groups from other countries have been encouraged in the setting of different consortiums and European projects, which displays the programme’s internationalisation capacity. With regard to this matter,some
of the groups from the programme have led
a proposal for a European project focussing on liver disease through fat accumulation. In the same fund-raising line, the groups in the programme were able to maintain their own lines for project financing and for recruiting human resources in competitive calls, which enables the critical mass of the programme to be maintained.
From the standpoint of cooperation between groups in the programme we have gone
on in the traditional approach of carrying out cooperative studies in the clinical area. One significant measure has nevertheless been the generation of a network of basic
likely to be published soon. It should similarly be highlighted that after creating a “map
of interactions” as mentioned in previous reports, some relevant cooperation schemes
are taking root between basic groups. Likewise, the frequent presence of collaborative studies between basic and clinical scientists has been kept up and, as occurred in previous years, some of the publications with greatest impact are precisely a result of these interactions.
As regards scientific results, production has continued to maintain a large proportion of publications in the first decile in this speciality, as well as the generation of clinical practice guidelines, as a final expression of the capacity for translation of research work to the patient. Without wishing to belittle the importance
of all the scientific results of the programme
at all,two major cooperative clinical studies
on patients with cirrhosis complications
should be stressed: one has enabled a more appropriate outline of the risk profile of patients with bleeding from esophageal varices with a view to urgent treatment with TIPS, and one characterising the prognostic impact of the presence of portosystemic shunts in patients with cirrhosis. In the field of transplantation
it has been possible to establish the value of antiviral treatment of hepatitis C in the post- transplant stage and show that elastographic monitoring proves to be of great value. Once again, these studies reflect not only great scientific value but also the capacity for translation to clinical practice.
CIBEREHD | ANNUAL REPORT 2018