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Scientific Programmes
Chronic Respiratory Diseases
Coordinator:
Juan Fernando Masa Jiménez
Asthma Line
• Researchers from La Paz, Fundación Jiménez Díaz and Hospital Vall d’Hebron have taken part in an international study on a cohort of 1167 patients on phenotypes connected with occupational asthma published in the journal Allergy.
• Two patents: “In vitro method for identifying stages of severity in patients with bronchial asthma” (P201730739) and “Differential biomarkers of asthma” (P201730947).
• The Hospital Clinic Barcelona has cooperated in an international study on the use of new technologies for the diagnosis, control and follow-up of rhinitis and asthma.
COPD Line
• A Clinical Research Collaboration has been set up with >33 European cohorts for the study of vital trajectories of lung function. https://www.ersnet.org/research/cadset- chronic-airway-diseases-early-stratification
severity of the obstruction, exacerbation and eosinophils.
Cancer Line
• An analysis has been made of the biology
of systems of the retrospective cohort. Experience with biomarkers in this setting has partly been responsible for a paper in the Journal of Thoracic Oncology on biomarkers connected with the detection of lung cancer.
• Respiratory sleep disorders are highly prevalent in both a lung cancer cohort and in the early detection cohort.
• Nocturnal hypoxaemia (T90%) was significantly correlated with positive results in cancer detection.
• The analysis of a combined cohort of patients from the SAILS study and the SAIL study found a greater risk of lung cancer in patients with obstructive sleep apnoea and nocturnal hypoxaemia.
Sleep Line
• Factors in early age connected with the development of COPD. Am J Respir Crit Care
Med 2018;198(7):973; Lancet Respir Med 2018;6(5):324-326 and Lancet Respir Med
2019. •
• In the analysis of the respiratory microbiome in severe COPD we have objectified the microbiome in stable COPD according to the
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Studies from the Spanish Sleep Network showed that handling sleep apnoea in primary care is a cost-effective alternative to the usual treatment given by specialised units.
Two studies show that in advanced age intermittent hypoxia does not cause the same alterations to the vascular wall, as well as in tumoral progression, as in younger individuals. This is presumably due to changes caused by age in the immune system.
In patients with OSA there is an increase of PD-1 / PD-L1, through the induction of the inducible factor by intermittent hypoxia. This gives biological plausibility to the increase
in the incidence and aggressiveness of the
CIBERES | ANNUAL REPORT 2018