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Host-Pathogen
Interaction Line.
Work has been done on three strategic lines: anti-virulence therapies, therapies addressing the host and systems of therapeutic administration. We have presented significant results in all three approaches:
• Pathoadaptive microbial evolution during chronic respiratory infection. We should stress the identification of patho-bacterial adaptation in the lung of COPD patients increasing their resistance to the bactericide effect of lipid inflammatory mediators.
Diffuse Respiratory Diseases
Coordinator:
Francisco Pérez Vizcaíno
• A paper on pulmonary hypertension associated with respiratory diseases of
the 6th World Symposium on Pulmonary Hypertension (TASK FORCE 10, Nice 2018).
• Major increase in the number of donations to the Spanish Pulmonary Hypertension Biobank, which has reached a figure of 450 patients registered in the Spanish Pulmonary Hypertension Registry.
• Participation in the International Consortium for Genetic Studies in Pulmonary Arterial Hypertension (ICON- PAH).
• Holding the second Reunión de Investigación en Hipertensión Pulmonar CIBERES. Universidad Complutense de Madrid, February 2018.
• Demonstration that pulmonary hypertension affects the intestinal microbiome in an experimental mouse model.
• Demonstration of the implication of signalling pathway JAK2 in pulmonary vascular remodelling.
• Analysis of the role of microRNAs in
• Subversion of respiratory immunity. We should underline the role of the SP-A protein of the pulmonary surface agent in the infection-immunity balance, a key aspect in limiting tissue damage after an infection.
• Preclinical valuation of antimicrobials. The immunogenic activity of chimeric fusion proteins inducing the production of cross- neutralising antibodies should be highlighted.
In 2018, the work done in this line has generated 18 scientific publications (7 additional works being reviewed), 1 patent, 30 (oral and poster presentations), 8 dissemination activities, and has led to the defence of 3 doctoral theses and 5 master theses.
pulmonary vascular remodelling in patients with COPD.
• Analysis of the role of proteins of the human immunodeficiency virus in the pulmonary vascular function.
• Analysis of geographical variability of mortality over time of critical patients with a need for invasive mechanical ventilation.
• Analysis of the effect of driving pressure on the mortality of critical patients needing invasive mechanical ventilation with no criteria of the acute respiratory distress syndrome.
• Participation in the preparation of recommendations on Use of ECMO in ICU (Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias).
• Coordination and management of the Tercer Simposio Internacional de Investigación Traslacional en Lesión Pulmonar Aguda (INSPIRES) (Amsterdam, 2018).
• National coordination of the international study on disconnection of mechanical ventilation (WEAN-SAFE) in ICUs.
• Participation in the National Consensus and Recommendations on the use of non- invasive mechanical ventilation (NIV) in patients with respiratory failure of the SEMICYUC, SEPAR, SEMES, SEDAR and SECIP associations.
• Identification of miRNAs, as possible targets regulating the inflammatory process in
CIBERES | ANNUAL REPORT 2018