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• e r, r e, s-s J, c Mi, D P, c D .. Primary Pre-
Most relevant struchosalasalVaDóoVasharMorellaet al
vention of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013
scientific Feb 25;.

articles
• García-hereDia a, KensicKi e, Mohney rP, rull a, triGuero i, Marsillach J et al.. Pa-
raoxonase-1 Deficiency Is Associated with Severe Liver Steatosis in Mice Fed a

High-fat High-cholesterol Diet: A Metabolomic Approach.J Proteome Res. 2013 Apr
5;12(4):1946-55.

• M-r a, V-q a, a s, r e, M-G Ma, s
eDinaeMónallVerDúueraltrranzosartínezonzálezacanella
e et al.. Gazpacho consumption is associated with lower blood pressure and redu-
ced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the

PREDIMED trial.Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):944-52.

• toleDo e, hu FB, estruch r, Buil-cosiales P, corella D, salas-salVaDó J et al.. Effect of
the Mediterranean diet on blood pressure in the PREDIMED trial: results from a ran-

domized controlled trial.BMC Med. 2013 Sep 19;11:207.

• tresserra-riMBau a, MeDina-reMón a, Pérez-JiMénez J, Martínez-González Ma, coVas Mi,

corella D et al.. Dietary intake and major food sources of polyphenols in a Spanish
population at high cardiovascular risk: the PREDIMED study.Nutr Metab Cardiovasc

Dis. 2013 Oct;23(10):953-9.

The Research Unit of Oxidative Pathology-University of Valencia (UV - POX )
Highlights
has worked actively in the scientific activities of the Thematic Network of Coo-
perative Research PREDIMED (G03/140). The most important contributions of

the group are related to the role of oxidative stress and damage to the genetic

material in the pathophysiology of cardiovascular and tumor diseases.
The group led by Prof. Guillermo Sáez has received research grants from public

institutions (PI10/0082; ACOM/2012/238; PI13/01848). It has been possible to

demonstrate the degree of oxidative modification of different organic molecules
in patients at high cardiovascular risk as well as the protective role observed

after intervention with Mediterranean diet supplemented with virgin olive oil

or nuts. We recently demonstrated the existence of lipid peroxidation damage
and oxidative DNA modification in the metabolic syndrome and morbid obesity

which is reversed by dietary intervention or surgical treatment respectively. Epi-

demiological data indicate that the Mediterranean diet is an important source of
polyphenols in fruits and olive oil form. Studies with experimental animal have

examined the bioavailability of the polyphenol hydroxytyrosol and its metabolic
derivatives. Both in cardiovascular risk and obese patients, polymorphisms and

enhanced expression of DNA repair enzymes involved in the pathway of p53

-dependent signaling molecular ( OGG1 , SIRT1 , FOXO1 ) have been identified
together with a reduction of antioxidant enzymes (SOD , GPx and catalase )
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involved in the control of reactive oxygen species. Biochemical and molecular 0
2
characterization of oxidative stress in tumors of the gastrointestinal tract has RT
proved a useful tool for a better understanding of the mechanisms of tumor pro- PO
E
gression and validation of the modified and mutagenic base 8-oxodG as a clinical R
marker in patients with gastric carcinoma.
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