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• e r, r e, s-s J, c Mi, D P, c D .. Primary Pre-
Most relevant struchosalasalVaDóoVasharMorellaet al
vention of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013
scientific Feb 25;.

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the Mediterranean diet on blood pressure in the PREDIMED trial: results from a ran-

domized controlled trial.BMC Med. 2013 Sep 19;11:207.

• corella D, carrasco P, sorlí JV, estruch r, rico-sanz J, Martínez-González Ma et al.. Me-
diterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism

on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in
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• G-F M, B M, M-G Ma, r e, c D, e r ..
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population at high cardiovascular risk: the PREDIMED study.Nutr Metab Cardiovasc
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The Nutrition and Lipid Metabolism Group works to determine the role of olive
Highlights
oil in human health. Since the PI described the hypotensive effect of olive oil for
the first time in 1996 (J. Hypertension), the group has developed many projects

about the relationship between olive oil and hypertension, which take advantage

of the group’s experience in the fields of lipid analysis and metabolism in both
laboratory animals and humans.

The group is specialized in the design of long term clinical trials on dietetic inter-

ventions and in postprandial phase of virgin olive oil and the Mediterranean diet.
The PI has been part of PREDIMED since its founding in 2003, in fact, she propo-

sed the idea of a separate branch devoted to virgin olive oil, contributing also the

control and acquisition that olive oil (valued at €1,200,000). She also significantly
contributed to the publication of the conclusions in the study published in the New

England Journal of Medicine, 2013.

Currently, we are developing the AGL2011-23430 project in PREDIMED patients,

which is studying the influence of the Mediterranean diet on the composition and
dynamics of the lipid membrane and lipoproteins with arthrogenic properties in

patients who suffer from metabolic syndrome.

The project objectives are centered on the discovery of dietary terpenic markers
in serum and/or cells, and the study of their correlation with lipid composition and

structure of the lipoproteins and blood cells. The second objective is based on the

quantification of the cellular levels of signal proteins (G proteins and protein ki- 13
nase C), adenylate cyclase and calculation of the correlation with blood pressure.
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At the moment, we are focusing on the project which is being developed by the RT
PO
group PREDIMED-PLUS 2013-2016, in which we are researching the mechanisms E
R
of hypertension, the composition and dynamics of the lipid membrane and lipo- AL
proteins with artherogenic properties.
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