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• Investigation of receptors heterodimeric with RXR (PPAR, FXR, LXR, etc.) and other

nuclear receptors participating in energy metabolism in liver, adipose, and skeletal
muscle tissues and in macrophages.

• Experimental models of metabolic syndrome in fructose-fed rats and rodent models of

senescence. Molecular characterization.

Most relevant • estruch r, ros e, salas-salVaDó J, coVas Mi, D PharM, corella D et al.. Primary Prevention
of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013 Feb 25;.
scientific
• ros e, hu FB. Consumption of plant seeds and cardiovascular health: epidemiological
articles
and clinical trial evidence.Circulation. 2013 Jul 30;128(5):553-65.
• c D, c P, s JV, e r, r-s J, M-G Ma .. Me-
orellaarrascoorlístruchicoanzartínezonzálezet al
diterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism
on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in

a high-cardiovascular-risk population.Diabetes Care. 2013 Aug 13;.

• Flores-Mateo G, roJas-rueDa D, Basora J, ros e, salas-salVaDó J. Nut intake and adiposi-
ty: meta-analysis of clinical trials.Am J Clin Nutr. 2013 Jun;97(6):1346-55.

• s-V a, c M, M-G r, c a, c F, r e. Eicosapentaenoic acid
alailaoFánateoalleGoenarroiVeiraos
in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with

familial hypercholesterolemia.J Nutr Biochem. 2013 Sep;24(9):1604-8.

Highlights
Among the actual research interests of the group: diet/nutrition and chronic diseases
(leadership of the PREDIMED randomized controlled trisal of nutritional intervention

for primary cardiovascular prevention), dietary determinants of cognitive function,
plant sterols, blood membrane fatty acids, genetic dyslipidemias, and vascular ima-

ging techniques, the most relevant projects and results are:
PROJECTS

• Exploitation of the data collected in the PREDIMED trial: effects of intervention

on neurocognition and incidence of dementia; preventive role of vegetable and
marine n-3 fatty acids; and role of dietary fructose on overall and cause-specific

mortality.
• The WAHA randomized clinical trial, a dual center study (Hospital Clínic of Barce-

lona and Loma Linda University, California) investigating the 2-y effects of a diet
supplemented with walnuts at 15% of energy vs. a control diet on age-related

cognitive declines and macular degeneration in 700 volunteers aged 63 to 79 y.
The recruitment of 350 participants in our center has been recently completed.

The trial will end in the fall 2015.

• To study the benefits of membrane fatty acid enrichment in n-3 fatty acids through
three main projects: A. Cardiovascular: predictive value in progression of sub-

clinical atherosclerosis and on 6-mo post-ischemic recovery of the myocardium
in patients surviving an acute coronary syndrome. B) Neurodegenerative disea- 13
0
ses: assessing changes in brain and circulating lipids in relation to progression of 2
Alzheimer’s disease. C) AIDS: effects of n-3 fatty acid incorporation into cultured RT
PO
lymphocytes on membrane raft organization and ensuing changes of HIV-1 infec- E
tivity.
R
AL
RESULTS
U
NN
• Publication of the main results of the PREDIMED trial in N Engl J Med, April 2013.
A
/
• Publication together with Frank Hu (Harvard University) of a comprehensive BN
review on the cardioprotective properties of the consumption of seeds (whole O
ER
grains, nuts, pulses, cocoa, and coffee) in Circulation, July 2013.
B
CI

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