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• e r, r e, s-s J, c Mi, D P, c D .. Primary Prevention
Most relevant struchosalasalVaDóoVasharMorellaet al
of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013 Feb 25;.
scientific
• Guasch-Ferré M, Bulló M, Martínez-González Ma, ros e, corella D, estruch r et al..
articles
Frequency of nut consumption and mortality risk in the PREDIMED nutrition
intervention trial.BMC Med. 2013 Jul 16;11:164.

• Díaz-lóPez a, Bulló M, Juanola-FalGarona M, Martínez-González Ma, estruch r, coVas

Mi et al.. Reduced serum concentrations of carboxylated and undercarboxylated
osteocalcin are associated with risk of developing type 2 diabetes mellitus in a high

cardiovascular risk population: a nested case-control study.J Clin Endocrinol Metab.
2013 Nov;98(11):4524-31.

• D-l a, c Mr, B M, M-M e, M-G Ma, e r
íazóPezhacónullóayMóasiPartínezonzálezstruchet
al.. Serum sTWEAK concentrations and risk of developing type 2 diabetes in a high
cardiovascular risk population: a nested case-control study.J Clin Endocrinol Metab.

2013 Aug;98(8):3482-90.

• FernànDez-roiG s, caVallé-Busquets P, FernánDez-Ballart JD, Ballesteros M, Berrocal-

zaraGoza Mi, salat-Batlle J et al.. Low folate status enhances pregnancy changes in
plasma betaine and dimethylglycine concentrations and the association between

betaine and homocysteine.Am J Clin Nutr. 2013 Jun;97(6):1252-9.

The effects of nutrition on health and its role in the incidence and progression of
Highlights
chronic diseases such as obesity, type 2 diabetes mellitus, metabolic syndrome
and cardiovascular disease are the neural axis of the current research lines that

are being conducted in the Unit of Human Nutrition. Many of the group efforts are

focused on the PREDIMED PLUS trial, aimed at assessing the effect of an inten-
sive treatment on lifestyle changes, including physical activity, energy-restricted

Mediterranean diet and behavioural treatment on cardiovascular disease preven-
tion. Other current studies are focused on evaluating the effect of several diet

components on markers of cardiovascular disease, as well as the mechanisms

that underlie the associations between diet and disease. The current research fo-
llows the group research trajectory that in the last years have resulted in the pu-

blication of numerous articles in scientific journals of international prestige. The

background generated during the last years has also allowed the design of seve-
ral clinical guidelines for the management of obesity and cardiovascular disease.

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