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RESEARCH GROUPS
Diabetes and Cardiovascular
Programme: P2
Lead Researcher: Benito de las Heras, Manuel R. Group members
STAFF MEMBERS: Fernández López, Silvia | García Gómez, Gema | González Trujillos, Elena ASSOCIATED MEMBERS: Bartolomé Herráinz, Alberto | Escribano Illanes, Óscar | Gómez Hernández, Almu-
dena | Guillén Viejo, Carlos | Pedromo Loaiza, Liliana | Viana Huete, Vanesa
Main lines of research
• Compensatory mechanisms to hepatic insulin resistance: Progression to type 2 diabetes. The role of the liver-pancreas endocrine axis in triggering beta-cell hyperplasia .
The role of autophagy, mitophagy and ER stress in the regulation of beta-cell pancreatic mass and beta-cell failure .
• Adipose organ inflammatory disease and the cardiovascular damage. BATIRKO/apoE -/- DKO mice: The role of the compensatory mechanisms of insulin resistance in the
aggravation/attenuation of inflammation, oxidative stress and vascular lesion in the aorta .
• Brown fat function/dysfunction and adipose organ inflammatory disease. New mouse models to study energy imbalance and body weight regulation: Brown adipose tissue-
specific knockout of IGFIR and IGFIR/IR DKO .
New mouse models of browning: Brown adipose tissue-specific knockout of p85 alpha/PI 3 kinase .
• Molecular mechanisms of insulin resistance: The role of IR isoforms in cardiomyocytes, endothelial and aortic vascular smooth muscle cells .
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CIBERDEM » Annual report 2014
