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Most relevant scientific articles
• Gil-de-Gómez l., astudillo a.m., GuiJas C., maGrioti V., kokotos G., BalBoa m.a. et al . Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimula- ted mouse peritoneal macrophages . Journal of Immunology . 2014;192(2):752-762 .
• Castano d., larequi e., Belza i., astudillo a.m., martínez-anso e., Balsinde J. et al . Cardiotrophin-1 elimina- tes hepatic steatosis in obese mice by mechanisms involving AMPK activation . Journal of Hepatology . 2014;60(5):1017-1025 .
• FuCHo r., martínez l., Baulies a., torres s., tarrats n., Fernández a. et al . ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis . Journal of Hepatology . 2014 .
• meana C., Pena l., lorden G., esquinas e., GuiJas C., ValdearCos m. et al . Lipin-1 integrates lipid synthesis with proin- flammatory responses during TLR activation in macrophages . Journal of Immunology . 2014;193(9):4614-4622 .
• GuiJas C., rodríGuez J.P., ruBio J.m., BalBoa m.a., Balsinde J. Phospholipase A2 regulation of lipid droplet for- mation . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids . 2014;1841(12):1661-1671 .
Institution: Agencia Estatal Consejo Superior De Investigaciones Científicas Contact: Instituto de Biología y Genética Molecular . C/ Sanz y Fores S/N . 47003 Valladolid Phone: (+34) 983 423 062 · E.mail: [email protected] · Website: http://www.balsinde.org
Highlights
ACTIVE RESEARCH GRANTS IN 2014
• “Lipid Pathways Regulating the Inflammasome: Role of Omega-3 Fatty Acids and Lipin-2”. Ministry of Eco- nomy and Competitiveness (SAF2013-48201-R). • “Mechanisms Governing Arachidonic Acid Availability in Human Macrophages”. Regional Government of Castile & Leon, Education Department (CSI007U13). • “Li- pin-1 Involvement in Intestinal Inflammation” . Regional Government of Castile & Leon, Health Department (BIO/VA/03-14) .
MOST RELEVANT RESULTS
• Demonstration that different phospholipase A2s expressed in the same cell act on different substrates. This may lead to different pro - and anti-inflammatory signals . We have detected subtle variations of specificity that might be useful for the design of selective inhibitors with possible therapeutic potential. • Demons- tration that lipin-1 is involved in pro-inflammatory macrophage activation through its regulatory effects on lipid metabolism .
TRAINING
• Doctoral thesis: “Role of Cytosolic of Group IVA phospholipase A2 in adipocyte differentiation and in the deve- lopment of obesity induced by a rich-fat diet”; Doctoral candiate, Lucía Peña Moreno . University of Valladolid .
OTHER ACTIVITIES
• One of our CIBERDEM contracted scientists, Dr. Clara Meana, spent 10 months in the laboratory of Prof. Ira Goldstein (New York University) with a fellowship from the COMP-DIATRAIN program .
The group IP, Prof . J . Balsinde, was distinguished by the Argentine Society for Biochemistry and Molecular Biology (SAIB) with the Alberto Sols Award Lecture, delivered during the 50 Congress SAIB in Rosario, Ar- gentina . He also served as “Fakultetsopponent” for the PhD Thesis Evaluation Committee of the Norwegian University of Science and Technology (Trondheim, Norway) . Finally, he continues to serve in the Editorial Boards of Journal of Lipid Research and Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids .
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