Page 69 - MEMOCiberdem014-ENG

Most relevant scientific articles
• GálVez-martin P., HmadCHa a., soria B., CalPena-CamPmanY a.C., Clares-naVeros B. Study of the stability of packaging and storage conditions of human mesenchymal stem cell for intra-arterial clinical appli- cation in patient with critical limb ischemia . European Journal of Pharmaceutics and Biopharmaceu- tics . 2014;86(3):459-468 .
• GálVez P., Clares B., BermeJo m., HmadCHa a., soria B. Standard requirement of a microbiological quality control program for the manufacture of human mesenchymal stem cells for clinical use . Stem Cells and Development . 2014;23(10):1074-1083 .
• delGado i., CarrasCo m., Cano e., Carmona r., GarCía-CarBonero r., marin-Gomez l.m. et al . GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice . Hepatology . 2014;59(6):2358-2370 .
• Cano d.a., soria B., martín F., roJas a. Transcriptional control of mammalian pancreas organogenesis . Cellular and Molecular Life Sciences . 2014;71(13):2383-2402 .
• oliVeras-lóPez m.-J., Berna G., Jurado-ruiz e., lóPez-GarCía de la serrana H., martín F. Consumption of extra-virgin olive oil rich in phenolic compounds has beneficial antioxidant effects in healthy human adults . Journal of Functional Foods . 2014;10:475-484 .
Highlights
Institution: Fundación para la Investigación y Docencia Sant Joan de Deu Contact: Centro Andaluz de Biología Molecular y Medicina Regenerativa · Avda. Américo Vespucio s/n. 41092 Sevilla · Phone: (+34) 954 977 944 · E.mail: [email protected] · Website: http;//www.cabimer.es
• Identification of GATA4 transcription factor as a liver fibrosis marker in biopsies from patients with SM . It has been studied the potential therapeutic target of GATA4 due to its ability to inactive stellate liver cells and allow the reversion of liver fibrosis .
• Characterization of human islet proteoma profile when culture in serum absence. In this situation human islets has a reticulum endoplasmic stress response . This will allow the design of tissue culture media able to improve human islet viability for islet transplantation .
• Development of two rodent models useful to study DM2 pathophysiology and to look for targets against DM2: i) knockout mice for presinilin . This model doesn´t develop SM, DM2 and NAFDL when fed with high caloric diets rich in saturated fats and sugars and ii) humanised mice with SM, DM2 and NAFDL . They are LDLR-Leiden -/- mice fed with diets with the same caloric profile, fats and saturated fats than spanish population .
• Improvement of maturation protocols to obtain beta cell surrogates from hESC and hIPS.
• Development of a tissue culture chemistry xenofree define medium to culture mesenchymal stem cells, from bone marrow and adipose tissue . The medium improve cell proliferation maintaining a stable cell genotype and fenotype and cell differentiation potential .
• Production of cells able to be used on cell therapy clinical assays under GMP conditions. Development of a certified quality system, under current legislation, to produce these cells . The cells have been used in cell therapy clinical assays to treat DM complications
www .ciberdem .org 69