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RESEARCH GROUPS
Molecular Mechanisms of Insulin
Resistance, Insulin Sensitivity, Islet
Development and Diabetic Complications
Programme: P2
Lead Researcher: Martínez Valverde, Ángela M. Group members
STAFF MEMBERS: Arroba Espinosa, Ana Isabel | González Rodríguez, Águeda | Murillo Gómez, Cayetana | Pardo Marques, Virginia
ASSOCIATED MEMBERS: Ahmed, Maysha | De Pablo Dávila, Flora | Hernández Sánchez, Catalina | Santamaría Pérez, Beatriz
Main lines of research
• Autophagy as a potential mediator of the progression of the non-alcoholic hepatic liver disease (NAFLD) in humans .
• Effect of fatty acids and lipid species in the cross-talk between inflammatory and insulin signalling in hepatocytes . • Drug-mediated insulin resistance in peripheral tissues: effects of chronic pharmacologycal treatments on insu-
lin signalling and glucose homeostasis
• Role of protein tyrosyne phosphatase 1B (PTP1B) in IGF-I and proinsulin-mediated signalling in the retina: possible benefits of PTP1B inhibition in the impairment of survival of photoreceptor cells .
• Analysis of the balance between stress and survival signalling pathways in diabetic retinopathy in humans .
• Study of the polarization of microglia in diabetic retinopathy .
• Characterization of diabetic nephropathy in IRS2-deficient mice: role of the critical nodes of the insulin sig- nalling in podocytes .
• Physiological role of proinsulin and the consequences of inappropriately high levels during cardiogenesis . • Role of atypical catecholaminergic cells in developing mouse pancreas . • Involvement of Tyrosine Hydroxilase in the metabolic adaptations to diet and temperature stressors .
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CIBERDEM » Annual report 2014