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Most relevant scientific articles
• González-rodríGuez a., reiBert B., amann t., Constien r., rondinone C.m., ValVerde a.m. In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice . DMM Disease Models and Mechanisms . 2014;7(9):1093-1100 .
• moBasHer m.a., de toro-martín J., González-rodríGuez a., ramos s., letziG l.G., James l.P. et al . Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes . Journal of Biological Chemistry . 2014; 289(42):29406-29419 .
• Vázquez P., roBles a.m., de PaBlo F., Hernández-sánCHez C. Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas . Diabetologia . 2014;57(11):2339-2347 .
• González-rodríGuez a., maYoral r., aGra n., ValdeCantos m.P., Pardo V., miquilena-Colina m.e. et al . Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD . Cell Death and Disease . 2014;5(4) .
• FranCés de, motiño o, aGrá n, González-rodríGuez a, Fernández-álVarez a, CuCarella C et al . Hepatic cyclooxyge- nase-2 expression protects against diet-induced steatosis, obesity and insulin resistance .Diabetes . 2014 .
Institution: Universidad Pablo de Olavide Contact: Instituto de Investigaciones Biomédicas Alberto Sols · C/ Arturo Duperier 4. 28029 Madrid Phone: (+34) 91 585 44 97 · E.mail: [email protected] · Website: www.iib.uam.es; www.cib.csic.es
Highlights
• Endoplasmic reticulum stress and autophagy as potential mediators for the progression of the non-alcoholic fatty liver disease (NAFLD) in humans .
• Pivotal role of the protein tyrosine phosphatase 1B (PTP1B) in the modulation of the responses to pro- and anti-in- flammatory challenges in macrophages: implications in the hepatic inflammation during the progression of NAFLD . • Drug-mediated insulin resistance in peripheral tissues: effects of chronic pharmacological treatments (paraceta-
mol and immunossupressants) on insulin signalling and glucose homeostasis . • Essential role of Keap1/Nrf2 signalling pathway in the modulation of the balance between death and survival
signalling pathways in the liver . • Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance by
the modulation of the insulin signaling cascade . • Role of PTP1B in IGF-I and proinsulin-mediated signalling in the retina: possible benefits of PTP1B inhibition in
the impairment of survival of photoreceptor cells . • Study of the polarization of microglia: implications in the progression of diabetic retinopathy. • Characterization of diabetic nephropathy in IRS2-deficient mice: role of the critical nodes of the insulin signalling
in podocytes . • Role of atypical catecholaminergic cells in developing mouse pancreas. • Involvement of tyrosine hydroxilase (TH) in the metabolic adaptations to diet and temperature stressors FUNDING:
• Inhibition of Protein Tyrosine Phosphatase 1B in the treatment of type 2 diabetes: effects in diabetic complica- tions and cell proliferation (SAF2012-33283) .
• Study of the mechanisms of insulin resistance: implications in obesity, diabetes and metabolic syndrome. S2010/ BMD-2423: MOIR-CM (Comunidad de Madrid) .
• Neurodegeneration as an early event in the Pathogenesis of Diabetic Retinopathy: A multicentric, prospec- tive, phase II-III, double blind randomized controlled trial to assess the efficacy of neuroprotective drugs ad- ministered topically to prevent or arrest Diabetic Retinopathy (EUROCONDOR) FP7-HEALTH-2011-two-stage HEALTH .2011 .2 .4 .3 .1 (2012-2016) .
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