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Most relevant scientific articles
• aLoBId I., BeNItez p., cardeLuS S., de BorJa caLLeJaS F., Lehrer-corIat e., puJoLS L. et al . Oral plus nasal corti- costeroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis . Laryngoscope . 2014;124(1):50-56 .
• de BorJa caLLeJaS F., MartINez-aNtoN a., aLoBId I., FueNteS M., cortIJo J., pIcado c . et al . Reconstituted human upper airway epithelium as 3-D in vitro model for nasal polyposis . PLoS ONE . 2014;9(6):- .
• coLoM a., GaLGoczY r., aLMeNdroS I., xauBet a., Farre r., aLcaraz J. . Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures . Journal of Biomedi- cal Materials Research - Part A . 2014;102(8):2776-2784 .
• GuILLaMat-pratS r., GaY-JordI G., xauBet a., peINado V.I., SerraNo-MoLLar a. . Alveolar Type II cell trans- plantation restores pulmonary surfactant protein levels in lung fibrosis . Journal of Heart and Lung Transplantation . 2014;33(7):758-765 .
• torreS-ateNcIo I., aINSua-eNrIch e., de Mora F., pIcado c., MartIN M. . Prostaglandin E2 prevents hype- rosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4 . PLoS ONE . 2014;9(10):- .
Highlights
Institution: Hospital Clínico y Provincial de Barcelona Contact: Hospital Clinico y Provincial de Barcelona . C/ Villarroel, 170 . 08036 Barcelona Phone: (+34) 93 451 09 93 · E .mail: cpicado@ub .edu
• Two works of the group resulted in the optimization of techniques useful for the studies using tri- dimensional cellular structures and for in vitro reconstruction of airway mucosa with all structural components . These methodologies are important because will allow to carry out mechanistic studies which could be extrapolated to in vivo scenarios .
• Experimental demonstration that transplantation of type II alveolar cells improve interstitial lung disea- se by promoting the recovery of the capacity to produce surfactant . This experimental study has been performed in parallel with a clinical trial with this new cellular therapy in humans .
• Physical exercise can precipitate bronchospasm in asthma patients. Bronchoconstriction appears to be due to the increase in the osmolarity of the liquid present in the apical part of airway epithelium buy still partially known mechanisms . Prostaglandin E2 prevents exercise-induced bronchospasm when administered prior to exercise . The mechanisms by which prostaglandin E2 abrogates bronchocons- triction remain to be elucidated . One study of the group demonstrated that prostaglandin E2 stabili- zes mast cells exposed to an osmotic challenge and prevents mast cells degranulation . This finding can account for the preventive effect of prostaglandin E of exercise-induced bronchoconstriction .
• Our group is one of the partners of the Integrated Care Pathway for Airway Disease (AIRWAY-ICP), which is one of the programs of the Global Alliance Against Chronic Respiratory Diseases .
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