Page 112 - MEMOCiberobn014-ENG

RESEARCH GROUPS
Obesidad, Neuroendocrinología
y Función Reproductora (UCO)
Programme: P2. Adipobiology; P3. Complications of Obesity; P6. Physiopathology of Body Weight Homeostasis
Lead Researcher: Tena Sempere, Manuel Group Members
STAFF MEMBERS: Barroso Romero, María Alexia | Molero Murillo, Laura | Rivero Cortes, Esther | Rodríguez Sanchez, Ana Belén .
ASSOCIATED MEMBERS: Aguilar Benítez de Lugo, Enrique | Benito López, Pedro | Castaño Fuentes, Justo Pastor | Castellano Rodríguez, Juan Manuel | Díaz Ruiz Ruiz, José Alberto | Fernández Fernández, Rafael | García Galiano, David | Gaytan Luna, Francisco | Gracia Navarro, Socorro | León Tellez, Silvia | Luque Huer- tas, Raúl Miguel | Malagón Poyato, María del Mar | Manfredi Lozano, María | Martínez Fuentes, Antonio Jesús | Peinado Mena, Juan Ramón | Pineda Reyes, Rafael | Pinilla Jurado, Leonor | Roa Rivas, Juan | Ruiz Pino, Francisco | Vázquez Martínez, Rafael Manuel | Vigo Gago, Eva María
Main lines of research
Our group implements integral analyses of various aspects of the pathophysiology of obesity and its complications, by the use of state-of-the-art techniques and cellular and animal models, as well as human samples . Our major research lines are:
• Adipobiology . We conduct proteomic analyses directed to the identification of novel molecular targets that are altered in the adipose tissue in obesity, with special interest in the characterization of the differential proteomic profile of the various fat depots and their different components (mature adipocytes vs . stromal-vascular fraction) . These studies aim also at the identification of novel molecular markers of adipocyte differentiation and insulin resistance .
• Adipose hormone signaling . We aim to characterize the receptors and signaling cascades of key adipokines, with special attention to the characterization of the receptors and intracellular signaling of adiponectin .
• Neuroendocrinology of metabolic alterations . We aim to characterize the endocrine and metabolic alterations of suitable preclinical models of deregulated energy balance, with special attention to the analysis of the contribu- tion of somatostatin/cortistatin, ghrelin, GH/IGF-1, insulin, their receptors and related molecules, involved in the neuro-hormonal mechanisms responsible for the control of food intake, glucose homeostasis and metabolism .
• Puberty, reproduction and obesity . We aim to characterize the alterations of puberty and reproductive function in conditions of energy imbalance, with special attention to the impact of obesity on puberty onset, gonadotropic function and fertility . Our interest is also covering the pathophysiology of early onset obesity and its link with pubertal disorders, addressed by the use of suitable preclinical models .
112 CIBEROBN » Annual report 2014