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• Gonadal factors and obesity . We study the metabolic alterations associated to gonadal and reproductive dys- function, with special attention to the analysis of the influence of nutritional and gonadal factors in the generation of obesity, as studies by the use of preclinical models of sequential obesogenic insults .
• Obesity and cancer . We aim to evaluate the alterations induced by obesity in the generation and progression of hormone-dependent cancers, such as breast, ovarian and prostate cancers, using both human samples and suita- ble animal models, with special attention to the analysis of neuroendocrine metabolic and inflammatory markers .
Most relevant scientific articles
• sánChez-Garrido M.a., ruiz-Pino F., ManFredi-lozano M., león s., GarCía-Galiano d., Castano j.P. et al . Obesity- induced hypogonadism in the male: Premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms . Endocrinology . 2014;155(3):1067-1079 .
• luque r.M., CórdoBa-ChaCón j., iBánez-Costa a., GesMundo i., Grande C., GraCia-naVarro F. et al . Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/ female mice . Endocrinology . 2014;155(4):1407-1417 .
• sanGiao-alVarellos s., Pena-Bello l., ManFredi-lozano M., tena-seMPere M., Cordido F. Perturbation of hypothalamic microrna expression patterns in male rats after metabolic distress: Impact of obesity and conditions of negative energy balance . Endocrinology . 2014;155(5):1838-1850 .
• leon s., GarCía-Galiano d., ruiz-Pino F., Barroso a., ManFredi-lozano M., roMero-ruiz a. et al . Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: Studies in the NPFF1 receptor null mouse . Endocrinology . 2014;155(8):2953-2965 .
• Martínez de Morentin P.B., González-GarCía i., Martins l., laGe r., Fernandez-Mallo d., Martínez-sánChez n. et al . Estra- diol regulates brown adipose tissue thermogenesis via hypothalamic AMPK . Cell Metabolism . 2014;20(1):41-53 .
Highlights
Institution: Universidad de Córdoba Contact: Facultad de Medicina . Universidad de Córdoba · Avd . Menéndez Pidal s/n . 14004 Córdoba Teléfono: (+34) 957 21 82 81 · E .mail: fi1tesem@uco .es · Website: www .uco .es
The group has continued its research activities in the area of the neuroendocrine control of body weight and the integral regulation energy balance, puberty and reproductive function . We have also completed studies in adipobiology and obesity and cancer . These activities have been carried out in close collaboration with other CIBERobn groups, and internationally recognized teams, and have resulted a high number of publications in reputed scientific journals at D1/Q1 .
The activities of the group have advanced in the definition of the mechanisms of obesity-induced male hypogonadism, using pre-clinical models . Hypogonadism might have a major role in the perpetuation of complications of the obesity; our results have allowed identification of the key role of Kiss1 system in this process . Similarly, our group has taken part in studies, coordinated by the group of the University of Santiago of our CIBER, aiming to shed light into the mechanisms whereby estrogens act at hypothalamic levels to regulate body energy homeostasis; a study that may help to explain the basis of body weight disorders linked to conditions such as menopause .
Our group has also participated in collaborative studies directed to identifying changes in the profiles of expression of miRNAs at the hypothalamus in conditions of metabolic stress and obesity, and has completed the first characterization of the reproductive and metabolic profiles of a model of inactivation of the receptor of the factor GnIH/RFRP-3; a recently identified signal that not only participates as inhibitory factor in the control of the reproductive axis, but also might play a role as orexigenic signal that stimulates food intake and body weight .
Finally, the group has also worked in the characterization of the metabolic effects of relevant neuroendocrine signals, e .g ., obestatin, in the definition of the molecular basis of the interaction between obesity, metabolic deregulation and cancer, and on the regulation of factors of adipose origin, as HMGB1, in conditions of obesity, and their possible role in the control of pancreatic beta cells .
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