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P6. PHYSIOPATHOLOGY OF BODY WEIGHT HOMEOSTASIS
This programme is based on conducting multidisciplinary studies in various pre-clinical and clinical models of energy homeostasis impairment as the basis for generating physiological knowledge (about mechanisms for controlling energy balance and related bodily functions) and pathological knowledge (relating to impairments in overweight conditions) that can be transferred to clinical practice for obesity and its associated co-morbidities .
Significant progress has been made in 2014 in the identification of new etiopathogenic mechanisms and therapeutic targets with translational potential in the field of obesity and its complications, essentially by means of studying pre-clinical models . New inter- and intra-cellular signals involved in controlling the energy intake and expenditure, acting both centrally and on peripheral tissues that are particularly relevant on a metabolic level, such as the liver, muscle and adipose tissues, have been identified for this
purpose . In addition, emphasis has continued to be placed on establishing interactions of the body weight control mechanisms and their dysfunction with biological determinants (sex, reproductive gestation and breastfeeding processes) by means of pre-clinical experimental models .
This programme consists of four subprogrammes . Important advancements have been made in all of them in 2014, and those aspects that must be pointed out are: a) the existence of a number of publications, several being of the highest international level, covering the work of the programme, and b) the frequent participation of several collaborating groups to conduct these studies, which is an is an unequivocal indicator of the programme’s cross-sectoral approach and the collaboration that it (and, in fact, the CIBER as a whole) generates in biomedical research in our area .
Besides the bibliometric data that CIBER possesses as regards scientific production, one or two outstanding publications optimally exemplifying the preceding two points are indicated below for each of the subprogrammes . The number superscripts indicate co-participation of PIs from different groups in that work, thereby showing the collaborative nature within the programme of those contributions .
Subprogramme 1 . INFLUENCE OF GONADAL AND NUTRITIONAL FACTORS, EARLY DEVELOPMENTAL EVENTS AND TRANSGENERATIONAL CHANGES ON THE DEVELOPMENT OF OBESITY.
• sánChez-Garrido Ma, ruiz-Pino F, ManFredi-lozano M, leon s, GarCia-Galiano d, Castaño jP, luque rM, roMero-ruiz a, Castellano jM, diéGuez C2, Pinilla l, tena-seMPere M1 . Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1- mediated mechanisms . Endocrinology . 2014 Mar;155(3):1067-79
Subprogramme 2 . GESTATIONAL AND BREASTFEEDING MECHANISMS IN PROGRAMMING OBESITY IN ADULTS.
• Palou M, PrieGo t, roMero M, szostaCzuk n, konieCzna j, CaBrer C, reMesar X2, Palou a1, PiCo C1 . Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling . Int J Obes (Lond) . 2015 Feb;39(2):339-45 .
• Martínez de Morentin PB, laGe r, González-GarCía i, ruíz-Pino F, Martins l, Fernández-Mallo d, GalleGo r, Fernø j, señarís r, saha ak, toVar s, diéGuez C1, noGueiras r1, tena-seMPere M2, lóPez M . Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats . Endocrinology . 2015 Mar;156(3):947-60
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CIBEROBN » Annual report 2014