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Subprogramme 3. UNDERLYING MECHANISMS OF BARIATRIC SURGERY, IDENTIFYING PROCESSES FOR THE DEVELOPMENT OF NEW, NON-SURGICAL THERAPEUTIC STRATEGIES.
• lanCha a, MonCada r, Valentí V, rodríGuez a, Catalán V, BeCerril s, raMírez B, Méndez-GiMénez l, FrühBeCk G, GóMez-aMBrosi j. Effect of sleeve gastrectomy on osteopontin circulating levels and expression in adipose tissue and liver in rats . Obes Surg . 2014 Oct;24(10):1702-8
Subprogramme 4. AFFERENT AND EFFERENT SIGNALS INVOLVED IN THE CONTROL OF ENERGY AND METABOLIC HOMEOSTASIS. INTEGRATION IN THE CENTRAL NERVOUS SYSTEM.
• Beiroa d, iMBernon M, GalleGo r, senra a, herranz d, Villarroya F3, serrano M, Fernø j, salVador j, esCalada j, diéGuez C1, loPez M, FrühBeCk G2, noGueiras r1 . GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK . Diabetes . 2014 Oct;63(10):3346-58 .
• Martínez de Morentin PB, González-GarCía i, Martins l, laGe r, Fernández-Mallo d, Martínez-sánChez n, ruíz-Pino F, liu j, MorGan da, Pinilla l, GalleGo r, saha ak, kalsBeek a, Fliers e, BissChoP Ph, diéGuez C1, noGueiras r, rahMouni k, tena-seMPere M2, lóPez M1 . Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK . Cell Metab . 2014 Jul 1;20(1):41-53 .
The successful scientific activity described would not have been possible without the transverse initiatives of the programme . Initiatives such as the programme for supporting the incorporation of pre-clinical models for shared use in CIBERobn and the maintenance and update of the of pre-clinical model database have continued and been further developed in 2014 .
The programme has also held an annual coordination meeting which discussed scientific and organisational aspects, consistent with what was done in previous years, with a very positive assessment . Specifically, the 2014 meeting was held on 19 December in the Universidad de Barcelona and consisted of two parts: a) an open scientific symposium (“Metabolism and adipose tissue, at the core of disease”) with the participation of PIs from the programme and scientists from abroad as honourable guests (S . Enerback, Göteborgs Universitet, Sweden; C . Wolfrum, ETH, Switzerland), and b) a meeting of only PIs from the programme and collaborators, where scientific and organisational aspects for 2015 were discussed .
In summary, the assessment of the programme’s activity and compliance with objectives was very satisfactory in 2014, and the prospects for 2015 are extremely promising .
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