Page 75 - MEMOCiberobn014-ENG

Most relevant scientific articles
• Fito M., estruCh r., salas-salVado j., Martinez-Gonzalez M.a., aros F., Vila j. et al . Effect of the Medite- rranean diet on heart failure biomarkers: A randomized sample from the PREDIMED trial . European Journal of Heart Failure . 2014;16(5):543-550 .
• hernáez a., Fernandez-Castillejo s., Farras M., Catalan u., suBirana i., Montes r. et al . Olive oil polyphenols enhance high-density lipoprotein function in humans: A randomized controlled trial . Arteriosclerosis, Thrombosis, and Vascular Biology . 2014;34(9):2115-2119 .
• GóMez M., Vila j., elosua r., Molina l., BruGuera j., sala j. et al . Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population . Atherosclerosis . 2014;232(1):134-140 .
• de la torre r., de sola s., Pons M., duChon a., de laGran M.M., Farre M. et al . Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans . Mo- lecular Nutrition and Food Research . 2014;58(2):278-288 .
• Mas-lorenzo a., BenaiGes d., Flores-le-rouX j.a., Pedro-Botet j., raMon j.M., Parri a. et al . Impact of Different Criteria on Type 2 Diabetes Remission Rate After Bariatric Surgery . Obesity Surgery . 2014;24(11):1881-1887 .
Highlights
Institution: Consorci Mar Parc Salut de Barcelona Contact: Consorcio Mar Parc de Salut de Barcelona Dr . Aiguader, 88, 1a Planta . 08003 Barcelona Teléfono: (+34) 93 316 07 24 · E .mail: mfito@imim .es · Website: http://www .imim .es
Highlighting the concession of a Joan Rodés (3 years) Contract to a medical doctor of the group, who will combine the field-work in the PREDIMEDplus Study at Institute Hospital del Mar (IMIM) in Barcelona with the clinical care task in the Endocrinology Service in the same hospital . Also remark the concession of two FIS projects to two researchers from the group: one on the enhancing effects exerted by alcohol on endogenous and exogenous synthesis of hydroxytyrosol and the other, on the role of iron-deficient state in the prognosis of patients with heart failure and valve disease .
Highlight the following results: 1/ to provide the highest level of scientific evidence on the effect of polyphenols-rich virgin olive oil on the HDL functionality and its oxidative status, in healthy subjects; 2/ it has been demonstrated the value of the oxidation of LDL, as a biomarker for predicting cardiovascular events in the general population; gradation of the oxidation of LDL particle is associated with obesity, hypertension and lipid profile in a transversal study (this work has constituted one of the papers in a Doctoral Thesis); 3/ in population at high cardiovascular risk, an intervention with Mediterranean diet has improved the concentration of the N-terminal pro-brain natriuretic, a heart failure biomarker related-peptide; a decrease in this natriuretic peptide is linked to an improvement of the oxidation of LDL; 4/ the epigallocatechin-3-gallate administration has been a useful tool to improve cognitive performance in sunjects with Down Syndrome, that effectiveness is linked to an inhibition of a tyrosine- (Y)-phosphorylation regulated kinase 1A (Dyrk1A); 5/ Type-2 diabetes mellitus remission is higher after laparoscopic surgery with gastric bypass (LRYGB) compared with other surgical techniques .
www .ciberobn .es 75