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the e ects of the lateral-Trendelenburg position in the prevention of ventilator-associated pneumonia The following review on the microbiome has also been published:
• Faner R, Sibila O, Agustí A, Bernasconi E, Chalmers JD, Huffnagle GB, Manichanh C, Molyneaux PL, Paredes R,Pérez Brocal V, Ponomarenko J, Sethi S, Dorca J, Monsó E The microbiome in respiratory medicine: current challenges and future perspectives Eur Respir J 2017 Apr 12;49(4)
It should also be stressed that the 22nd International Symposium on Infections in the Critically Ill Patient (Oporto 2017) was arranged
Di use Respiratory Diseases
Coordinator: Francisco Pérez Vizcaíno Main achievements in 2017:
• 1st Meeting for Research into Pulmonary Hypertension in Spain, which involved over 80 re- searchers from both CIBERES and other organisations
• Getting under way the Spanish Registry on Pulmonary Hypertension associated with Respira- tory Disease (REHAR)
• Demonstration of the di erent e ect of targeted therapy of pulmonary hypertension on circu- lating biomarkers (endothelial progenitor cells and endothelial microparticles)
• Publication of the Guía de Diagnóstico y Tratamiento de la Hipertensión Pulmonar, backed by the Sociedad Española de Neumología y Cirugía Torácica (SEPAR), with the participation of several CIBERES members
• Study of the role of miR-1 on pulmonary endothelial dysfunction and the activity and expres- sion of channels of voltage-dependant potassium
• Establishment of an international consortium for the analysis of physiopathological mecha- nisms involved in pulmonary hypertension associated with co-infection with schistosoma and HIV:
• Determination of the status of vitamin D, its prognosis value in patients with arterial pulmo- nary hypertension
• Worsening of pulmonary hypertension through a vitamin D de cit in the rat
• First results with advanced imaging techniques (PET and MRI) in pulmonary hypertension
• Generation of TERT and TERC constructions with mutations of patients with idiopathic pulmo- nary brosis and transfection to cell lines
• Determination of the e ect of GSE4 expression on telomerase activity by in vitro TRAP test in cells expressing GSE4 or treatment with GSE4 nanoparticles
• Determination of the e ect of PLGA/PEI nanoparticles charged with GSE4 in a model of pul- monary brosis with bleomycin and monitoring by means of SPECT: inhibition of brosis markers, deposition of collagen and recovery of telomerase activity
• Insulation and characterisation of mesenchymal stem cells of patients with idiopathic pulmo- nary brosis and in donors