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In patients with the obesity-hypoventilation syndrome, treatment in the medium term with VNI or CPAP is more e ective than modi cation of their lifestyle
For the rst time we have described that intermittent hypoxia (IH) increases the incidence of tumours in di erent organs and spontaneous tumorigenesis, particularly in the lung
The SAVE study has shown that treatment with CPAP in patients with OSA is not e ective for secondary cardiovascular prevention
Cancer line:
We go on working with three lung cancer cohorts (IASLC, CIBERES and Early-COPD) of patients in stages Ip/IIp
An intramural grant has been awarded for the study of the ndings from these cohorts based on sys- tems biology
The recruitment of patients with lung cancer in advanced stages for the study of epigenetics in ganglion samples
The screening cohort has over 700 individuals and the recruitment of patients in the SAIL and SAILS studies has been completed
Infectious Respiratory Diseases
Coordinator: Antoni Torres Martí
The MTBVAC vaccine is safe and immunogenic in murine and neonatal human models and gives more protection than BCG There are derivatives which express antigens of other infections New vaccines based on other lines of tuberculosis are made
There are genetic, genomic and epidemiological databases of strains causing outbreaks, which enable identifying prevalent strains among originating populations in countries with a high immigration rate and designing molecular tests which detect transmission and identify clonal strains
The immunological and transcriptional response is studied with lesions and blood of active or latent tuberculosis patients The storage of samples, diagnosis of tuberculosis by means of nanoparticles and tests to detect resistances have been improved There are metabolites in the urine which are connected with tuberculosis
Families of new anti-tuberculosis compounds and their targets have been characterised Nanoparticles with bedaquiline or rifampicin are active against the bacillus Nyaditum resae is studied in a comorbidity model in experimental animal models There are clinical tests with ibuprofen Tobacco smoke reduces the presence of tuberculosis macrophages and the activity of rifampicin
Our researchers have demonstrated that 60 % of the serotypes causing CAP by pneumococcus in Spain are contained in conjugated vaccine VCN 13v Roughly 20% of the exacerbations of bronchiectasis treated in hospital are caused by multi-resistant bacteria
In 2017 Pneumocoper has contributed to publishing new international guides of clinical practice in respiratory infections
Seven experimental randomised studies have been completed on the prevention and treatment of serious pulmonary infections and are currently being sent to journals with a high scienti c impact factor A randomised clinical test in over 400 patients has been published (Intensive Care Med 2017) on
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