Page 105 - MemoriaCIBER-2017ENG

Scienti c Programmes
Chronic Respiratory Diseases
Coordinator: Juan Fernando Masa Jiménez Asthma line:
As part of the project entitled ‘Study of the underlying mechanisms of the genesis and evolution of asth- ma’, the group has included roughly 300 patients in the cohort, creating a biorepository which stores biological samples to use in this and future projects
The group has obtained funding from the Instituto de Salud Carlos III (FIS PI17/01950), SANOFI and CI- BERES, with an intramural project for identifying miRNAs as possible biomarkers and new therapeutic targets in asthma and COPD
One patent (P201730947) has been applied, which will enable developing di erential biomarkers in asthma
COPD line:
The pro les for di erentiated gene expression in patients with fragile COPD and eosinophilia have been determined
The methodology for studying the respiratory microbiome has been de ned (IJCOPD-2017, FMicrobi- ol-2017; ATM- 2017; ERJ-2017; BMCMicrobiol-2017; Arch-Bronconeumol-2017)
A relationship between respiratory microbiome and COPD phenotypes was established Adaptive traits of micro-organisms with regard to the evolution of COPD have been de ned The bases for antibiotic resistance of NTHi have been de ned (Cell InfectMicrobiol. 2017) Multilevel description of markers associated with exacerbation (ERJ-2017)
Picking up in vivo images of speci c pulmonary neutrophilic in ammation with nanotracer Ga68 (SciRep-2017)
The in uence of pulmonary function in early ages was revealed with prognosis (LancetRM-2017) De- scription of the relationship between the endotype and response to treatment (Lancet-2017)
OSA line:
A population study covering 70,469 patients treated for sleep apnoea (OSA) with CPAP shows that the treatment is associated with a reduction of mortality in men
The most complete national collection of patients with suspected OSA is available, including over 700 subjects
A speci c score may be useful for predicting OSA patient’s response to CPAP treatment in terms of blood pressure control
Handling OSA with home respiratory polygraphy is similarly e ective to polysomnography, at a lower cost
Treatment for OSA in primary care can be given for roughly half of the patients with suspected OSA