Page 54 - MemoriaCIBER2019-ENG

54
CIBER Annual report 2019
Programmes
PROGRAMME 1. Epidemiology, Genetics and epigenetics of diabetes mellitus.
Chronic complications and comorbilities
Coordinator: Ángela Martínez Valverde
Epidemioloy of diabetes mellitus,
its chronic complications and comorbilities
In the framework of the di @ betes study, the association between milk consumption and the presence of a better metabolic profile in the general population has been confirmed, as well as the increased risk of dysglicemia and insulin resistance in geographical areas with higher mean temperatures ( Valdés et al., Eur J Endocrinol. 2019). The lipoprotein profile has been completed by means of NMR, glycosylated proteins and low molecular weight metabolites in the 5,072 samples of the cohort of the di @ betes study, which has allowed to initiate an extensive phase of data analysis with the participation of several CIBERDEM groups.
CIBERDEM is participating in the International Study of Tertiary Prevention of type 1 diabetes in children and adoles- cents with intraganglionic GAD (glutamic acid decarboxylase) (DIAGNODE study). In this multicentre clinical trial, a CIBERDEM group coordinates the participation of the 10 clinical groups in Spain.
Genetics, epigenetics and
environmental factors in the development of diabetes and its complications
Atherosclerotic plaques in the carotid arteries of patients with type 1 diabetes have been characterised for the first time by ultrasound, with a higher frequency of plaques containing calcium found compared to people without diabe- tes (Castelblanco et al., J Clin Med. 2019 ). The study has been carried out in collaboration with CIBEROBN.
It has been reported that macrophage-specific reverse cholesterol transport (CRT) decreases in patients with type 2 diabetes and that, although overexpression of APOA1 improves this phenotype in a murine model of diabetes and obesity, it increases fatty liver and weight (Méndez-Lara et al., Int J Mol Sci. 2019). In collaboration with CIBERCV, the oxidation of certain amino acids of APOA1 has been characterised, which are key in the alteration of CRT and common to various diseases that carry great cardiovascular risk, such as abdominal aortic aneurysm (Martínez-López et al., EBioMedicine. 2019).